The BRICS countries (Brazil, Russia, India, China, and South Africa) aim to achieve Sustainable Development Goals 3 and 16, which involve promoting human well-being for all and building strong institutions and governance. This study examines the AII-HWBG nexus contingent on governance indicators within the BRICS nations in 2012-2022 using the Cross-Sectional Augmented Autoregressive Distributed Lag (CS-ARDL) technique. Its findings reveal a long-term relationship among variables with varied causality directions and point to the necessity of integrating governance quality into AII to boost HWBG in both the short- and long-term perspective. Since AII has not so far been used to support HWBG there is a dire need for caution when considering AII’s interaction with institutional governance, economic governance, control of corruption, political stability, regulatory quality and voice and accountability. The paper highlights the crucial role of governance quality in shaping the way AI investment impacts the human well-being. To ensure an overall improvement of well-being, priority should be given to strategies that promote positive synergy between AI investment and governance while mitigating possible harmful effects. Carefully targeted measures in governance areas can create an environment conducive to AI development where it will significantly benefit the citizens of the BRICS countries.