Asymmetric Reductive Amination of α-Keto Acids Using Ir-Based Hydrogen Transfer Catalysts: An Access to Unprotected Unnatural α-Amino Acids
Takaaki Yajima,
Akito Katayama,
Tsubasa Ito
et al.
Abstract:A direct asymmetric reductive amination
of α-keto acids catalyzed
by Cp*Ir complexes bearing a chiral N-(2-picolyl)sulfonamidato
ligand is described. The combined use of optically active 2-phenyglycinol
as an aminating agent is effective for the chemo- and stereoselective
transfer hydrogenation using formic acid. The subsequent elimination
of the hydroxyethyl moiety by orthoperiodic acid can afford various
unprotected α-amino acids in satisfactory isolated yields (20
examples) with excellent optical purities (… Show more
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