Asymmetric reduction of various types of ketones with lithium aluminum hydride partially decomposed with (-)-N-methylephedrine and N-ethylaniline.

The Epoxy‐Ramberg–Bäcklund Reaction (ERBR): A Sulfone‐Based Method for the Synthesis of Allylic Alcohols

“…); nBuLi in hexanes (1.6 , (g) trans-3-Methyl-4-phenyl-3-buten-2-ol (5k): Clear oil with spectroscopic data consistent with literature. [30] (h) 1-Benzylsulfanylbutan-2-ol: Clear oil with spectroscopic data consistent with literature. 2, 128.0, 128.7, 129.1, 129.3, 130.3, 131.3, 133. 17.2, 21.3, 21.6, 33.3, 33.8 …”

“…in THF) gave the corresponding trisubsti-tuted allylic alcohol 5k in 92 % yield as one detectable double-bond isomer. The trans-alkene geometry was assigned on the basis of chemical shift values reported in the literature [30] and nOe studies. Similarly, the phenyl derivative 4l gave the trisubstituted alkene trans-5l selectively.…”

Characterization of Yeast Strains with Ketoreductase Activity for Bioreduction of Ketones

“…Then the mixture was extracted with EtOAc (3 × 20 mL), the unified organic layers were dried on sodium sulfate and concentrated under reduced pressure. The resulting product was purified by plate chromatography (silica gel; eluent: hexane- H-NMR data agreed with the reported spectra [33].…”

Novel Hydrolases from Thermophilic Filamentous Fungi for Enantiomerically and Enantiotopically Selective Biotransformations

“…After shaking the reaction mixture at 1000 rpm, room temperature for 5 h, the enzyme was removed by filtration. The solvent was distilled off from the filtrate by rotary evaporation and the residue was separated by vacuum chromatography (silica gel, hexaneacetone, 10 : 1, v/v) to give alcohol (S) [40] and (R)-2. [41] Enantiomeric Excess Determination of 4a and 4b…”