Asymmetric Reactions

Abstract

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A Magnetoclick Imidazolidinone Nanocatalyst for Asymmetric 1,3‐Dipolar Cycloadditions

“…[14] Herein we report the design and synthesis of a new magnetic nanoparticle functionalized chiral imidazolidinone catalyst using 1,3-dipolar azide-alkyne cycloaddition which catalyzes the 1,3-dipolar cycloaddition of nitrones 1 and 2 with a,b-unsaturated aldehydes 3 to provide isoxazolidines 4 and 5 in a highly stereoselective manner (Scheme 1).…”

Axially Chiral BINIM and Ni(II)-Catalyzed Highly Enantioselective 1,3-Dipolar Cycloaddition Reactions of Azomethine Ylides and N-Arylmaleimides

“…The catalytic asymmetric 1,3-dipolar cycloaddition reaction is one of the most useful methods for the construction of optically active five-membered heterocycles . More importantly, the reactions between azomethine ylides (from imines) and activated alkenes afforded tetrasubstituted pyrrolidine or proline derivatives in one step along with the four contiguous chiral centers .…”

Highly Enantioselective Copper(I)−Fesulphos-Catalyzed 1,3-Dipolar Cycloaddition of Azomethine Ylides

“…The catalytic asymmetric 1,3-dipolar cycloaddition reaction is conceptually an extremely powerful and efficient strategy for the enantioselective construction of five-membered heterocycles . Of particular interest is the reaction between azomethine ylides and activated alkenes to form functionalized pyrrolidines, which are key units in medicinal chemistry and highly valuable synthetic building blocks 2b.…”