Asymmetric Photoredox Reactions Without Photocatalysts

Recent advances in the asymmetric catalytic construction of oxa-quaternary carbon centers

“…Although photocatalysis opens up a new window for carbonyl chemistry, visible light-induced catalytic asymmetric transformations remain elusive and pose a formidable challenge. 26 In 2022, Feng and coworkers reported an excellent enantioselective radical photoaddition to ketones through a Lewis acid-enabled photoredox catalysis, giving various enantioenriched aza-heterocycle-based tertiary alcohols in good to excellent yields and enantioselectivities (Scheme 17). 27 Diverse experimental and computational evidence proved that the key to success is the binding of a chiral Lewis acid with a ketone to result in the formation of a temporary photocatalyst, which could not only facilitate SET to generate a nucleophilic radical species under visible light excitation but also perform enantiocontrolled radical addition to the ketone.…”

Recent Advances in Visible Light‐induced Asymmetric Transformations of Carbonyl Compounds into Chiral Alcohols

“…This comprehensive review will provide an overview of recent advances in photoinduced asymmetric transformations of carbonyl compounds for the synthesis of chiral alcohols, mainly including two modes (Figure 3). One is the use of single catalyst regime, which means serving as dual‐functional chiral catalysts for photocatalytic process and enantiocontrol [41] . The other is the synergistic catalysis which utilizes a chiral catalyst to control stereoselectivity and additional photosensitizer to promote photoredox process [8,42–43] …”

“…One is the use of single catalyst regime, which means serving as dual-functional chiral catalysts for photocatalytic process and enantiocontrol. [41] The other is the synergistic catalysis which utilizes a chiral catalyst to control stereoselectivity and additional photosensitizer to promote photoredox process. [8,[42][43]…”