Asymmetric Periflexural Exanthem of Childhood

Unilateral Laterothoracic Exanthem – Asymmetric Periflexural Exanthem of Childhood – a Case Report and Literature Review

“…The exanthem first began as a centrifugal periflexural spread during the initial 8 days, followed by more widespread skin eruptions (1). Although both sides of the body are affected in 70% of cases, almost all have a unilateral predominance (1,2,6,8). Spontaneous regression of exanthem occurs between the third and sixth week, as in our patient (1,2,5,6).…”

“…ULE is an uncommon disease which mostly affects children between one and five years of age. The eruptions usually start in the axilla, like in our case (1,2,5,6,8). The clinical course of the rash had two phases.…”

“…ULE is more frequent in the winter and spring (1, 2, 5 -8). However, interhuman transmission was not clearly documented (8). In a microbiological case-control study, Coustou et al were not able to point to a specific virus or bacteria (14).…”

“…Spontaneous regression of exanthem occurs between the third and sixth week, as in our patient (1,2,5,6). Pruritus and mild local lymphadenopathy is seen in about 50% patients (1,2,5,8).…”

“…In our patient, serological findings indicated a recent parvovirus B19 infection, suggesting a causal relation. Many authors have supposed a viral trigger because of the children's age, frequent association of upper respiratory tract or digestive prodromes, serologic findings, spontaneous resolution in a few weeks, and seasonal fluctuations in incidence (1,6,8,11). Duarte et al considered a relationship to infections with adenovirus, parainfluenza virus 2 or 3, parvovirus B19, human herpes virus 6 or 7, and Epstein-Barr virus (7).…”