Asymmetric Oxazaborolidine‐Catalyzed Reduction of Prochiral Ketones with N‐tert‐Butyl‐N‐trimethylsilylamine—borane.

Abstract

Enantioselective syntheses Enantioselective syntheses O 0031Asymmetric Oxazaborolidine-Catalyzed Reduction of Prochiral Ketones with N-tert-Butyl-N-trimethylsilylamine-borane. -The title reagent is reported as an efficient borane source under conditions A). -(HUERTAS, R. E.; CORELLA, J. A.; SODERQUIST*, J. A.; Tetrahedron Lett. 44 (2003) 24, 4435-4437; Dep. Chem., Univ. Puerto Rico, Rio Piedras 00931, P. R.; Eng.) -Mais 36-027

Stable Continuous Operation of a Biphasic Enantioselective Enzymatic Reduction

“…In these reactions enzymes are unmatched in enantioselectivity compared to chemical homogeneous catalysts. The most challenging substrate is butanone where to the best of our knowledge the best results for hydrogenation yielded enantiomeric excess ee=0.72 (enantiomeric ratio er=6) utilising Ru based catalysts, so far [4][5][6].…”