Asymmetric N-oxidation catalyzed by bisguanidinium dinuclear oxodiperoxomolybdosulfate
Wentao Wu,
Esther Cai Xia Ang,
Xinru Xu
et al.
Abstract:N
-oxides play a pivotal role in natural products and emerging drug design, while also serving as valuable ligand scaffolds in organometallic chemistry. Among heteroatom oxidations, the conversion of amines to
N-
oxides is a critical and challenging facet. We present here a highly enantioselective
N-
oxidation methodology for both cyclic and acyclic amines. The method employs an ion-pair catalyst comprising a chiral bisguanidinium [
BG
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