2007
DOI: 10.2478/v10007-007-0027-3
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Asymmetric membrane capsule for osmotic delivery of flurbiprofen

Abstract: Utilization of osmotic pressure as a driving force for delivery of pharmaceutical agents in a controlled pattern for a prolonged period of time is a well-established fact. The concept of osmotic drug delivery was first introduced by Theeuwes (1). The simplest design of an osmotic drug delivery system consists of an osmotically active core surrounded by a semipermeable membrane, with one or more delivery orifices through which the drug is delivered in a controlled fashion. Various modifications of the basic des… Show more

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Cited by 15 publications
(8 citation statements)
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“…The in vitro release study showed that as the proportion of osmogent and solubilizing agent was increased the release rate also increased. A good correlation was observed between the zero-order rate constant and the amount of the osmogent and solubilizing agent used (46).…”
Section: Scientific Studiesmentioning
confidence: 71%
“…The in vitro release study showed that as the proportion of osmogent and solubilizing agent was increased the release rate also increased. A good correlation was observed between the zero-order rate constant and the amount of the osmogent and solubilizing agent used (46).…”
Section: Scientific Studiesmentioning
confidence: 71%
“…(1)) [16][17][18][19][20]. Drug loaded AMCs were prepared by incorporating controlled dose of PE-HCl in the shell, mixed with sodium chloride in polythene bag and sealed with ethanolic solution of Ethyl cellulose (EC).…”
Section: Preparation Of Asymmetric Membrane Capsules Of Pe-hclmentioning
confidence: 99%
“…Then the capsules were suspended separately in beakers containing 250 mL of water and sodium chloride solution (10% w/v ). The capsules were observed visually for the release of colored dye [7, 8]. …”
Section: Methodsmentioning
confidence: 99%