Asymmetric maturation of a dimeric transfer RNA precursor

DNA sequence of the transfer RNA region of bacteriophage T4: implications for transfer RNA synthesis.

“…The nucleotide sequences of small precursor RNAs for most of these have been determined (ref. 1 and references cited therein; unpublished data), and the synthetic steps leading from these intermediates to the mature molecules are known (2). Less is known about the initial steps responsible for formation of the small precursor RNAs. We know that the small precursor RNAs are not primary transcripts, and evidence from in vitro transcription studies of the T4 tRNA coding sequences (3), which are grouped together in a small region of the T4 genome ( Fig.…”