Asymmetric Localization of a Mammalian Numb Homolog during Mouse Cortical Neurogenesis

Zhong, Weimin; Feder, John N.; Jiang, Mingming; Jan, Yuh Nung

doi:10.1016/s0896-6273(00)80279-2

Cited by 445 publications

(403 citation statements)

References 51 publications

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“…The molecules so far identified, such as Notch, Numb, Miranda, Staufen, and Prospero (10,20,45,46), have been shown to exhibit either basal or apical ''capping'' before division in static studies. Importantly, the fate molecule parcellation model only works in conjunction with variable orientations of the final cleavage plane.…”

Section: Cleavage Plane Orientation Does Not Always Predict Daughter mentioning

confidence: 99%

Mitotic spindle rotation and mode of cell division in the developing telencephalon

Haydar

Ang

Rakić

2003

Proc. Natl. Acad. Sci. U.S.A.

217

187

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The mode of neural stem cell division in the forebrain proliferative zones profoundly influences neocortical growth by regulating the number and diversity of neurons and glia. Long-term time-lapse multiphoton microscopy of embryonic mouse cortex reveals new details of the complex three-dimensional rotation and oscillation of the mitotic spindle before stem cell division. Importantly, the duration and amplitude of spindle movement predicts and specifies the eventual mode of mitotic division. These technological advances have provided dramatic data and insights into the kinetics of neural stem cell division by elucidating the involvement of spindle rotation in selection of the cleavage plane and the mode of neural stem cell division that together determine the size of the mammalian neocortex.T he number and diversity of cells in the cerebral cortex is due, in great measure, to the mode of progenitor cell division in the proliferative ventricular zone (VZ) before birth (1-4). At each mitotic division, the proliferative fate of each daughter cell, either reentering or exiting the cell cycle, dramatically influences neocortical growth (5). Symmetrical founder cell divisions, which predominate early, yield more progenitors and lead to an exponential expansion of the VZ population. In contrast, asymmetrical divisions, which prevail during later stages of neurogenesis, lead to cell commitment and diversity of the cortical architecture (1). Critical parameters of cortical growth are, therefore, the duration of the early symmetrical division phase and the time and extent of the transition to the asymmetrical mode of division (1-3). Despite the importance of this developmental strategy for brain growth, it is unknown how conversion between these major types of mitotic divisions is achieved in the VZ of the mammalian forebrain.The current model for how different daughter cell fates result from asymmetric stem cell divisions assumes that cytoplasmic fate-determining molecules are unequally distributed during mother cell mitosis (6-9). This asymmetrical segregation can initiate diverse cellular programs during development of the daughter cells, including restriction of potential and differentiation (10-13). A prerequisite for producing asymmetric allocation of intracellular contents, observed in rodent telencephalon, is rotation and alignment of the mitotic spindle before division (14). Supporting such a causative role in cell fate determination, spindle movement before anaphase and the choice of the final cleavage plane has been correlated with daughter cell behavior in both invertebrates (6, 15-19) and vertebrates (refs. 10, 13, 20, and 21; see Fig. 1). In mammalian studies, however, determination of the molecular mechanisms linking spindle orientation, parcellation of intracellular factors, and fate determination has suffered from the lack of an intact model system. We sought to develop the capability for real-time analysis of these issues in living tissue that preserves the three-dimensional relationship between stem and ...

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Section: Cleavage Plane Orientation Does Not Always Predict Daughter mentioning

confidence: 99%

Mitotic spindle rotation and mode of cell division in the developing telencephalon

Haydar

Ang

Rakić

2003

Proc. Natl. Acad. Sci. U.S.A.

217

187

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“…Numb, a phosphotyrosine-binding domain protein, is asymmetrically segregated during the division of sensory organ precursor cells and serves to determine cell fate through its inhibition of Notch (Guo et al 1996;Zhong et al 1996). In cell culture, Numb binds directly to Notch and interferes with Notch-mediated nuclear translocation of Suppressor of Hairless (Frise et al 1996).…”

Section: Down-regulation Of Notch Signalingmentioning

confidence: 99%

When cell biology meets development: endocytic regulation of signaling pathways

2002

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“…36 Mammalian homologues of these genes have been identified. 37,38 In addition, current models of Notch function indicate that generation of ICN must occur in order for a Notch signal to be transduced (reviewed in Ref. 1).…”

Section: Figurementioning

confidence: 99%

Notch-1 and Notch-2 exhibit unique patterns of expression in human B-lineage cells

et al. 2000

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Asymmetric Localization of a Mammalian Numb Homolog during Mouse Cortical Neurogenesis

Cited by 445 publications

References 51 publications

Mitotic spindle rotation and mode of cell division in the developing telencephalon

Mitotic spindle rotation and mode of cell division in the developing telencephalon

When cell biology meets development: endocytic regulation of signaling pathways

Notch-1 and Notch-2 exhibit unique patterns of expression in human B-lineage cells

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