Asymmetric hydrogenation of quinolines with recyclable and air-stable iridium catalyst systems

Preparation of Galipea officinalis Hancock type tetrahydroquinoline alkaloid analogues as anti-tumour agents

“…1) Xu et al 2005;Chan et al 2007;). In vitro cytotoxicity on Hep3B human hepatocellular carcinoma cell was evaluated with compounds 2a-l as a preliminary anti-cancer screening for the selected alkaloids.…”

Recyclable Stereoselective Catalysts

“…The immobilized catalyst was reused seven times without any negative impact on the reaction enantioselectivity. This protocol was also extended to other chiral diphosphine ligands [38] .…”

Enantioselective Synthesis of Alcohols and Amines by Iridium‐Catalyzed Hydrogenation, Transfer Hydrogenation, and Related Processes

“…DMPEG-immobilized iridium complexes containing similar C 2 -symmetrical ligands (Xyl-P-Phos (51), Cl-MeO-BiPhep (39 b), SynPhos (46), and DifluorPhos (49)) gave comparable results; ee values up to 92 % and the catalyst could be recycled (Scheme 19). [54] The same authors prepared four generations of {IrA C H T U N G T R E N N U N G (BINAP)}-cored dendrimers (52 a-d) that showed excellent enantioselectivities (up to 93 %) in the hydrogenation of quinolines (10) (Scheme 20). [55] The encapsulation in the dendrimer framework prevented formation of inactive dimers and resulted in a very active system reaching TOFs up to 3450 h À1 and TONs up to 43000.…”