Asymmetric dimethylarginine predicts appropriate implantable cardioverter-defibrillator intervention in patients with left ventricular dysfunction

Abstract

Asymmetric dimethylarginine and the Arg/ADMA ratio seem to be new biomarkers for the prediction of ventricular tachycardia/ventricular fibrillation episodes and of appropriate ICD intervention in pts with left ventricular ejection fraction dysfunction (LV-EF ≤ 35%), suggesting a value for risk stratification in these pts.

Serum amine-based metabolites and their association with outcomes in primary prevention implantable cardioverter-defibrillator patients

“…10 In a study of 106 primary prevention ICD patients from Germany, ADMA was also found to be associated with the risk of appropriate ICD therapy. 11 Unlike ADMA, its structural isomer SDMA, has been less well investigated and is thought to be biologically inert as it does not directly inhibit NO synthesis. 12 However, recent studies have reported associations of SDMA with cardiovascular outcomes and mortality in various study populations including patients undergoing coronary angiography, 10 and with coronary heart disease.…”