Asymmetric Dimethylarginine (ADMA) in Pediatric Renal Diseases: From Pathophysiological Phenomenon to Clinical Biomarker and Beyond

Hsu, Chien‐Ning; Tain, You‐Lin

doi:10.3390/children8100837

Cited by 7 publications

(9 citation statements)

References 83 publications

(132 reference statements)

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“…According to Shafi et al, ADMA and SDMA are pseudo-uremic toxins that can induce toxicity through a number of mechanisms, including disturbances in the synthesis of nitric oxide and the formation of reactive oxygen species [ 33 ]. Plasma ADMA levels do not correlate with blood creatinine or eGFR levels in children and adolescents with CKD, most likely because most ADMA is enzymatically degraded, in the opinion of Hsu Chien-Ning et al [ 34 ]. While our observations showed a statistically negative correlation between ADMA and GFR in children with CKD ( Figure 4 ), as also reported by Benito [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Nitric Oxide Synthesis Metabolites—As Potential Markers in Chronic Kidney Disease in Children

Piechowicz

Gamian

Chukwu³

et al. 2022

CIMB

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Nitric oxide (NO) is an important signaling molecule for many physiological and pathological processes. Diseases associated with abnormal NO synthesis include cardiovascular diseases, insulin-dependent diabetes, or chronic kidney disease (CKD). The aim of the paper was to evaluate NO synthesis metabolites, i.e., asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), dimethylamine (DMA), arginine, citrulline in plasma of patients with different severity of CKD and to seek possible links between these parameters and the development of this disease. Forty-eight CKD children and thirty-three age-matched controls were examined. Patients were divided into groups depending on the CKD stages (Group II-stage II, Group III-stage III, Group IV-stage IV, and Group RRT children on dialysis). To determine the concentrations of the above-mentioned metabolites in plasma liquid chromatography-mass spectrometry was used. There were significant differences observed in levels of ADMA, SDMA, DMA, and citrulline between control vis CKD groups (p values ranging from <0.001 to 0.029). Plasma arginine concentration was also higher in CKD patients compared to the control group but statistically insignificant. ADMA levels in CKD children were statistically significantly higher in relation to particular stages of CKD (RRT vis II stage of CKD: p = 0.01; RRT vis III-IV stages of CKD: p < 0.046). Citrulline levels in CKD children were statistically significantly higher in RRT group vis control (p < 0.001). Children with CKD develop disturbances in most metabolites of NO synthesis. Dialysis children treated show the greatest disturbances of plasma ADMA and citrulline levels. ADMA seems to be a good indicator of the gradual progression of the CKD, which is proved by the negative correlation with eGFR.

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Section: Discussionmentioning

confidence: 99%

Nitric Oxide Synthesis Metabolites—As Potential Markers in Chronic Kidney Disease in Children

Piechowicz

Gamian

Chukwu³

et al. 2022

CIMB

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“…Competitive inhibitor of eNOS such as ADMA lowers NO synthesis ( Hsu and Tain, 2021 ). Decreased NO also gives rise to unabated ET-1 actions that contribute to vasoconstriction, thereby increasing blood pressure ( Böger and Ron, 2005 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of Piper sarmentosum Roxb. on hypertension and diabetes mellitus: A systematic review and meta-analysis

et al. 2022

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Hypertension and diabetes mellitus are among the most prevalent diseases affecting people from all walks of life. Medicinal herbs have garnered interest as potential agents for the prevention and treatment of diabetes mellitus and hypertension due to their multiple beneficial effects. Piper sarmentosum Roxb. (PS) is an edible medicinal plant that has been traditionally used in Asia for treating hypertension and diabetes mellitus. This review is aimed to provide comprehensive information from the literature on the effects of PS on hypertension and diabetes mellitus. A computerized database search was performed on Scopus, PubMed and Web of Science databases with the following set of keywords: Piper sarmentosum AND diabetes mellitus OR diabetic OR diabetes OR hyperglyc*emia OR blood glucose OR HbA1c OR glycated h*emoglobin OR h*emoglobin A1c OR hyperten* OR blood pressure. A total of 47 articles were screened and 14 articles published between the years 1998 until 2021 were included for data extraction, comprising of six articles on antihypertensive and eight articles on antidiabetic effects of PS. These studies consist of two in vitro studies and eleven in vivo animal studies. Meta-analysis of three studies on hypertension showed that PS versus no treatment significantly lowered the systolic blood pressure with mean difference (MD) −39.84 mmHg (95% confidence interval (CI) −45.05, −34.62; p < 0.01), diastolic blood pressure with MD −26.68 mmHg (95% CI −31.48, −21.88; p < 0.01), and mean arterial pressure with MD −30.56 mmHg (95% CI −34.49, −26.63; p < 0.01). Most of the studies revealed positive effects of PS against hypertension and diabetes mellitus, suggesting the potential of PS as a natural source of antidiabetic and antihypertensive agents.

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“…In CKD, renal L-citrulline uptake is reduced, the amount of L-citrulline converted to L-arginine in the kidney is diminished, and plasma L-citrulline levels and turnover are increased [ 74 ]. In children with CKD stages 1–3, a high plasma ratio of L-citrulline-to-L-arginine significantly correlated with abnormal ABPM profile, including nocturnal hypertension, increased diastolic BP load, and nocturnal BP non-dipping [ 75 ]. Another study indicated that the plasma ratio of L-arginine-to-ADMA, an index of NO bioavailability [ 76 ], was elevated in children with CKD stages 2–3 and positively correlated with BP.…”

Section: Cardiovascular Risks and Biomarkers In Pediatric Ckdmentioning

confidence: 99%

“…Several studies found plasma ADMA levels were elevated in children with pre-dialysis CKD [ 78 , 79 , 80 ]. Additionally, elevated plasma ADMA levels occur in parallel with increased BP loads [ 75 ] and AI [ 77 ].…”

Section: Cardiovascular Risks and Biomarkers In Pediatric Ckdmentioning

confidence: 99%

Cardiovascular Risks of Hypertension: Lessons from Children with Chronic Kidney Disease

Tain

Hsu²

2022

Children

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Hypertension is the most common complication of chronic kidney disease (CKD) in children, having a strong association with subsequential cardiovascular disease (CVD). In pediatric CKD, a considerable percentage of children with hypertension are undiagnosed or undertreated. Prior research has evaluated structural and functional markers of subclinical CVD and biomarkers in adults with CKD, while ideal biomarkers in pediatrics are still insufficiently studied. The ultimate goal of this review is to summarize what is currently known about state of hypertension, cardiovascular risk factors, and potential CVD markers/biomarkers in children with pre-dialysis CKD. We discuss omics-related biomarkers and the pathophysiologic processes of endothelial dysfunction, kidney injury, oxidative stress and inflammation that are classified by specific biomarkers. Moreover, we illustrate the existing challenges and highlight the paucity of pediatric CKD research to evaluate these CVD biomarkers for future clinical pediatric practice. Thus, achieving clinical utility of CVD biomarkers for use in pediatric CKD remains a significant challenge requiring additional efforts.

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Asymmetric Dimethylarginine (ADMA) in Pediatric Renal Diseases: From Pathophysiological Phenomenon to Clinical Biomarker and Beyond

Cited by 7 publications

References 83 publications

Nitric Oxide Synthesis Metabolites—As Potential Markers in Chronic Kidney Disease in Children

Nitric Oxide Synthesis Metabolites—As Potential Markers in Chronic Kidney Disease in Children

Effects of Piper sarmentosum Roxb. on hypertension and diabetes mellitus: A systematic review and meta-analysis

Cardiovascular Risks of Hypertension: Lessons from Children with Chronic Kidney Disease

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