Asymmetric Dimethylarginine (ADMA) and Progression of Nephropathy in Patients with Type 2 Diabetes

Assal, Heba Sayed; Younes, Khaled; Alsayed, Ahmed; Hasan, Nehal Salah; Ali, Ahmed Nabil

doi:10.1007/s00596-009-0115-0

Cited by 3 publications

(1 citation statement)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Decreased NO production can lead to vasoconstriction, increased peripheral resistance, glomerular hypoperfusion that will exacerbate the state of endothelial dysfunction. 6,7 Asymmetric dimethylarginine is a major inhibitor of endogenous eNOS with 202 Da molecular weight that is produced continuously produced protein metabolism of the cell nucleus during the protein turnover process. After the process of proteolysis, ADMA compounds will be found in the cytoplasm and can be detected in the blood circulation.…”

Section: Introductionmentioning

confidence: 99%

Differences of Asymmetric Dimethyl Arginine Level in Patients With Diabetic Nephropathy and Non-Diabetic Nephropathy

Wisudawati

Rita

Lismayanti

et al. 2018

Indonesian J. Clin. Pathol. Med. Lab.

View full text Add to dashboard Cite

Endothelial dysfunction occurs early in Diabetic Nephropathy (DN), characterized by elevated Asymmetric Dimethylarginine (ADMA) levels. Increased ADMA levels may inhibit endothelial Nitric Oxide Synthase (eNOS) production which are required for Nitric Oxide (NO) formation. Decreased NO levels can increase peripheral resistance and exacerbate the endothelial dysfunction. By knowing the difference of ADMA levels in DN and non-DN patients can help the follow-up and management for the progression of endothelial dysfunction. The purpose of this research was to know the difference of ADMA levels in DN and non-DN by a cross-sectional observational analytical method in 53 diabetes mellitus patients at the Dr. Hasan Sadikin Hospital Bandung (December 2016-July 2017). Urine samples were examined to calculate urinary creatinine albumin ratio (uACR) and serum for ADMA levels. Asymetric dimethylarginin was examined by micro ELISA. Most of the subjects were males (60.38%) with the highest age in the range of 55-64 years (45.28%). Increased ADMA levels were found in 100% of DN and 18.5% of non-DN. Median ADMA levels were found in DN 1.01(0.73-2.25) µmol/L and non-DN 0.57(0.27-1.17) µmol/L, showing a significant difference of ADMA levels (p<0.001). High ADMA levels showed endothelial dysfunction in DN. Serum ADMA levels in DN patients were higher than in non-DN.

show abstract

Section: Introductionmentioning

confidence: 99%