Asymmetric deletion of the junction between the short unique region and the inverted repeat does not affect viral growth in culture and vaccine-induced immunity against Marek's disease

Development of an Effective Polyvalent Vaccine against both Marek's and Newcastle Diseases Based on Recombinant Marek's Disease Virus Type 1 in Commercial Chickens with Maternal Antibodies

“…In the poultry industry, four recombinant viruses (rFPV [1,5,8,14,18,25,31,34,35,59], rHVT [13,17,28,41,44,53], adenovirus [51], and rMDV1 [45,47,49,54,62]) that express foreign antigens of other avian pathogens (including NDV [14, 17, 24, 28-30, 35, 47, 53, 58], MDV [31,33,42,44,69], infectious bursal disease virus [1,5,13,18,19,51,62], avian influenza virus [2,3,5,56,59,61,65,66], avian leukosis virus [34], and avian reticuloendotheliosis virus [8]) have been developed, and these viruses showed significant vaccine efficacy against a variety of avian diseases. Further, rHVT, rMDV1, and rFPV expressing NDV antigens have been constructed and used to FIG.…”

“…Congr., p. [150][151][152][153][154][155]1992). Of these sites, those of the US3 and US10 genes and the junction region between the unique short (U S ) and short inverted repeats were nonessential not only for viral growth in culture but also for vaccineinduced immunity (45,49,54). In addition, other groups reported several nonessential sites within U S repeat for viral growth in culture (9,37,38).…”