Asymmetric cell division of stem cells in the lung and other systems

Berika, Mohamed; Elgayyar, Marwa E.; El-Hashash, Ahmed

doi:10.3389/fcell.2014.00033

Cited by 36 publications

(25 citation statements)

References 67 publications

(124 reference statements)

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“…Ultrastructural and immunohistochemical findings from these lambs suggest a potential connection between BPV-associated carcinogenesis and the stem cell mode of division. There is some evidence that loss of regulation of ACD, a property of stem cells 40 , could be a key oncogenic event 41 , 42 . Indeed, it has been shown that a shift of the physiological asymmetric mode of division toward a symmetric one appears to occur in oral and mammary stem cells resulting in cancer stem cell (CSC) formation 42 – 44 .…”

Section: Discussionmentioning

confidence: 99%

Oral fibropapillomatosis and epidermal hyperplasia of the lip in newborn lambs associated with bovine Deltapapillomavirus

Roperto

Russo

Corrado

et al. 2018

Sci Rep

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Congenital fibropapillomatosis of the gingiva and oral mucosa and epidermal hyperplasia of the lip are described, for the first time, in two newborn lambs. Expression of the E5 oncoprotein of bovine deltapapillomavirus types 2 (BPV-2) and -13 (BPV-13) was detected in both fibropapillomas and the hyperplastic epidermal cells suggesting the BPV infection was the cause of the proliferative lesions. No DNA sequences of BPV-1 and BPV-14 were detected. Both BPV-2 and BPV-13 DNA were also amplified from peripheral blood mononuclear cells (PBMCs) of the newborn lambs’ dams. The concordance between BPV genotypes detected in the blood of dam and the oral and skin pathological samples of their offspring suggests that a vertical hematogeneous transmission was most likely source of BPV infection. Immunoblotting revealed the presence of E5 dimers allowing the viral protein to be biologically active. E5 dimers bind and activate the platelet derived growth factor β receptor (PDGFβR), a major molecular mechanism contributing to disease. The detection of E5 protein within the proliferating cells therefore adds further evidence that the BPV infection was the cause of the proliferative lesions seen in these lambs. This is the first evidence of vertical transmission of BPVs in sheep resulting in a clinical disease.

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Section: Discussionmentioning

confidence: 99%

Oral fibropapillomatosis and epidermal hyperplasia of the lip in newborn lambs associated with bovine Deltapapillomavirus

Roperto

Russo

Corrado

et al. 2018

Sci Rep

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“…An extreme example is the polar body extrusion during oogenesis in which asymmetric division results in the formation of a large oocyte and a small polar body [4]. Asymmetric division is also exploited by stem cells for self-renewal and differentiation, and loss of the division asymmetry may cause tumorigenesis [5-7]. For example, in Drosophila, neuroblasts undergo asymmetric division to generate each a neuroblast and a smaller daughter cell – the ganglion mother cell (GMC) [5, 8, 9].…”

Section: Introduction To Cytokinesismentioning

confidence: 99%

Mechanics and regulation of cytokinesis in budding yeast

Bhavsar-Jog

2017

Seminars in Cell & Developmental Biology

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Cytokinesis is essential for the survival of all organisms. It requires concerted functions of cell signaling, force production, exocytosis, and extracellular matrix remodeling. Due to the conservation in core components and mechanisms between fungal and animal cells, the budding yeast Saccharomyces cerevisiae has served as an attractive model for studying this fundamental process. In this review, we discuss the mechanics and regulation of distinct events of cytokinesis in budding yeast, including the assembly, constriction, and disassembly of the actomyosin ring, septum formation, abscission, and their spatiotemporal coordination. We also highlight the key concepts and questions that are common to animal and fungal cytokinesis.

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“…Cancer stem-like cells tend to divide symmetrically generating two unique stem cells to expand the stem cell pool ( 36 , 37 ). In stem cells enriched from spheres of esophageal cancer cells, we identified the frequent occurrence of symmetric division through H3K9me2 staining ( 24 , 25 , 38 – 40 ), as presented in Fig. 3B and C .…”

Section: Resultsmentioning

confidence: 93%

Nano Let-7b sensitization of eliminating esophageal cancer stem-like cells is dependent on blockade of Wnt activation of symmetric division

Pang

Liu

et al. 2017

International Journal of Oncology

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The poor therapy response and poor prognosis of esophageal cancer has made it one of the most malignant carcinoma, and the complicated multidisciplinary treatment failed to achieve a long-term disease-free survival. To diagnose esophageal cancer at an earlier stage, and to improve the effect of anticancer therapy would improve the therapeutic efficacy. After retrospective analysis of the cancer samples of patients who received esophagectomy, we found the relevance between ratio of either ALDH1 or CD133-positive cancer stem cells and 2-year recurrence. Higher ratios of cancer stem cells indicated later clinical stages, and Wnt signaling activation was more frequent in later esophageal carcinoma. Further in bench studies, we explored the suppressive roles and the mechanisms involved in Let-7 on self-renewal in ECA-109 and ECA-9706 esophageal cancer stem cells. Isolated cancer stem cells naturally divide symmetrically and are therapy resistant. Therapy of fluorouracil and docetaxel both enriched the stem cells, proving the resistant characteristics of cancer stem cells. Wnt activation stimulated more symmetric division of stem cells, resulting in self-renewal promotion, which could be blocked by Let-7 overexpression. Furthermore, enforced Let-7 sensitized the stem cells to chemotherapies in a Wnt pathway inhibition-dependent manner, contributing to Let-7 sensitization of chemotherapeutic response. Wnt activation weakened the suppressive Let-7b through the sponge functions of CCAT-1, forming the negative feedback loop of Let-7b/Wnt/CCAT1. These results identified the crucial participation of stem cells in esophageal cancer occurrence and progression as the potent indicator, and also indicate the potential powerful agent of Let-7 nano-particles in treatment of cancer.

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Asymmetric cell division of stem cells in the lung and other systems

Cited by 36 publications

References 67 publications

Oral fibropapillomatosis and epidermal hyperplasia of the lip in newborn lambs associated with bovine Deltapapillomavirus

Oral fibropapillomatosis and epidermal hyperplasia of the lip in newborn lambs associated with bovine Deltapapillomavirus

Mechanics and regulation of cytokinesis in budding yeast

Nano Let-7b sensitization of eliminating esophageal cancer stem-like cells is dependent on blockade of Wnt activation of symmetric division

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