2016
DOI: 10.1039/c6ra07256a
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Asymmetric cationic lipid based non-viral vectors for an efficient nucleic acid delivery

Abstract: Cationic lipids have been extensively studied for their ability to complex with nucleic acids to condense and consequently deliver them into the cells.

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Cited by 17 publications
(13 citation statements)
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“…Consequently, to improve drug efficacy and minimize systemic toxicity, we developed a PEGylated liposomal formulation of N19 (LN19). In our study we used a novel asymmetric cationic lipid (labeled as D1) synthesized in our laboratory to make an efficient PEGylated liposome and simultaneously to increase cellular uptake by tumor cells due to the total positive charge of the liposomes . These experiments demonstrate that all of the liposomal formulations have a mean diameter of less than 100 nm (Table ), which is excellent for penetrating the blood vessels surrounding the tumor and subsequent endocytosis by the tumor cells.…”
Section: Discussionmentioning
confidence: 99%
“…Consequently, to improve drug efficacy and minimize systemic toxicity, we developed a PEGylated liposomal formulation of N19 (LN19). In our study we used a novel asymmetric cationic lipid (labeled as D1) synthesized in our laboratory to make an efficient PEGylated liposome and simultaneously to increase cellular uptake by tumor cells due to the total positive charge of the liposomes . These experiments demonstrate that all of the liposomal formulations have a mean diameter of less than 100 nm (Table ), which is excellent for penetrating the blood vessels surrounding the tumor and subsequent endocytosis by the tumor cells.…”
Section: Discussionmentioning
confidence: 99%
“…Although the permanent positive charges bring cationic lipids high transfection efficiency and endosomal escape ability, they may cause severe cytotoxicity and short systemic circulation time [ 149 ]. To solve this problem, researchers proposed adjusting the charge ratio of lipid to nucleic acids [ 173 , 174 , 175 ]. However, the consequences of those attempts are not satisfying.…”
Section: Modifications Of Lipid-based Nanoparticlesmentioning
confidence: 99%
“…The particle size was measured ten-times in triplicate using dynamic light scattering and applying zero-field correction. Similarly, zeta potential was measured ten-times by assessing the viscosity, 0.89 cP; dielectric constant, 79; and temperature, 25 • C, and then Smoluchowski approximation was used to derive the average value [33]. To assess the stability of liposomes, FITC-/DEX-containing liposomes were prepared and then stored at RT.…”
Section: Zatasizer-based Determination Of Liposomal Size Potential and Stabilitymentioning
confidence: 99%