Asymmetric and symmetric dimethylarginine concentration as an indicator of cardiovascular diseases in rheumatoid arthritis patients: a systematic review and meta-analysis of case-control studies

Zafari, Parisa; Zarifian, Ahmadreza; Alizadeh‐Navaei, Reza; Taghadosi, Mahdi; Rafiei, Alireza; Samimi, Zahra; Niksolat, Fatemeh

doi:10.1007/s10067-019-04713-z

Cited by 24 publications

(17 citation statements)

References 45 publications

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“…The immune-related molecular mechanisms that underlie the pathogenesis of CAD and RA have many similarities [ 6 ]. The consensus among experts is that immune dysfunction caused by multiple immune cell derangement is the root of RA, particularly the imbalance of Th17 and regulatory T (Treg) cells in peripheral blood [ 7 – 9 ].…”

Section: Introductionmentioning

confidence: 99%

Reduction of peripheral regulatory T cells in active rheumatoid arthritis patients with coronary artery disease

Wang

et al. 2021

BMC Immunol

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Objective To identify lymphocyte and CD4 + T cell subset characteristics, particularly regulatory T cells (Tregs), in active rheumatoid arthritis (RA) patients with coronary artery disease (CAD). Methods A total of 54 RA patients with CAD (RA-CAD group), 43 RA patients without CAD (pure RA group), and 43 healthy controls (HC group) were enrolled. The absolute number and frequency of lymphocyte subpopulations and CD4 + T cell subsets were analyzed by flow cytometry. Serum levels of cytokines were analyzed using a cytometric bead array. Clinical and laboratory data were collected retrospectively and their correlation with CD4 + T subsets were analyzed. Results There was a significant decrease in the absolute number of Treg cells (CD4 + CD25 + Foxp3 + T cells) in the RA-CAD group compared to the pure RA group (p < 0.001). Similarly, both the absolute number (p = 0.001) and frequency (p = 0.011) of Tregs in the RA-CAD group were decreased compared to the HCs, causing a Th17/Treg imbalance (p = 0.044). No difference was found in the absolute number and frequency of Treg cells between the pure RA and HC groups. However, the absolute Th17 cell count was increased in the pure RA group (p = 0.032). The serum level of cytokine IL-17 was lower in the RA-CAD group than in the pure RA group (p = 0.023). In the RA-CAD group, the Treg number was negatively correlated with the RA disease activity score and ESR value, and LDL and ApoB100 levels were negatively correlated with the number of Th17 cells. Conclusions Active RA patients with CAD sustain more severe immune tolerance damage and Th17/Treg disorder. Monitoring of lymphocyte and CD4 + T cell subsets, particularly Treg cells, is crucial to understanding immune status in this group. Focusing on RA activity and CAD risk control, immune-regulatory therapy based on the Treg level may be more beneficial for RA patients with CAD.

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Section: Introductionmentioning

confidence: 99%

Reduction of peripheral regulatory T cells in active rheumatoid arthritis patients with coronary artery disease

Wang

et al. 2021

BMC Immunol

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“…The average age of diagnosis for lung cancer is 70, while the average age of death is 72. Lung cancer‐related mortality rises with age until about the age of 80–85 when cardiovascular disorders became the most prevalent cause of mortality (Siegel et al, 2019; Zafari et al, 2020). There are discrepancies in lung cancer incidence between countries, and smoking has a substantial impact on this pattern (Bray et al, 2018).…”

Section: Lung Cancermentioning

confidence: 99%

The roles, controversies, and combination therapies of autophagy in lung cancer

Wang

Zhou

Yang

2021

Cell Biology International

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Lung cancer is one of the leading causes of death among men and women worldwide. The disease initially has a silent phenotype, which leads to the progression of the disease and ultimately the lack of proper response to routine treatments. Autophagy, known as an intracellular “recycle bin” for the degradation of defective proteins and molecules, is one of the mechanisms that has been considered in the context of cancer in recent years. This study aims to provide a comprehensive review of published articles on autophagy in the context of lung cancer to have a complete view of the role of autophagy in lung cancer and its possible treatments. PubMed, Scopus, and Google Scholar were searched until June 15 to find related articles. No specific search filters or restrictions were applied. The results were entered into reference management software for aggregation and management. The full text of all articles was screened and studied. In conclusion, studies on the exact function of autophagy in lung cancer are contradictory, but what can be concluded from a review of literature on lung cancer is that targeting autophagy combined with traditional routine therapies such as chemotherapy, especially in advanced stages of lung cancer, can be an effective anticancer approach.

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“…ADMA may be increased by systemic inflammation and subsequently lead to endothelial dysfunction in patients with coronary heart disease or rheumatoid arthritis (RA) [34]. The link of ADMA and inflammation in RA patients is meanwhile confirmed by different studies and meta-analyses [35][36][37] suggesting that ADMA may constitute as vascular risk marker in this vulnerable patient collective. This is further supported by a study in RA patients demonstrating an association of ADMA with homocysteine and with a methylenetetrahydrofolate reductase (MTHFR) polymorphism which are implicated in atherosclerosis [38].…”

Section: The Relation Of Adma and Sdma To Atherosclerotic Diseasementioning

confidence: 99%

Arginine Derivatives in Cerebrovascular Diseases: Mechanisms and Clinical Implications

Große

Schwedhelm

Worthmann

et al. 2020

IJMS

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The amino acid L-arginine serves as substrate for the nitric oxide synthase which is crucial in vascular function and disease. Derivatives of arginine, such as asymmetric (ADMA) and symmetric dimethylarginine (SDMA), are regarded as markers of endothelial dysfunction and have been implicated in vascular disorders. While there is a variety of studies consolidating ADMA as biomarker of cerebrovascular risk, morbidity and mortality, SDMA is currently emerging as an interesting metabolite with distinct characteristics in ischemic stroke. In contrast to dimethylarginines, homoarginine is inversely associated with adverse events and mortality in cerebrovascular diseases and might constitute a modifiable protective risk factor. This review aims to provide an overview of the current evidence for the pathophysiological role of arginine derivatives in cerebrovascular ischemic diseases. We discuss the complex mechanisms of arginine metabolism in health and disease and its potential clinical implications in diverse aspects of ischemic stroke.

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Asymmetric and symmetric dimethylarginine concentration as an indicator of cardiovascular diseases in rheumatoid arthritis patients: a systematic review and meta-analysis of case-control studies

Cited by 24 publications

References 45 publications

Reduction of peripheral regulatory T cells in active rheumatoid arthritis patients with coronary artery disease

Reduction of peripheral regulatory T cells in active rheumatoid arthritis patients with coronary artery disease

The roles, controversies, and combination therapies of autophagy in lung cancer

Arginine Derivatives in Cerebrovascular Diseases: Mechanisms and Clinical Implications

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