Asymmetric alterations of white matter integrity in patients with insomnia disorder

Rostampour, Masoumeh; Gharaylou, Zeinab; Rostampour, Nima; Kaveh, Donya; Noori, Khadijeh; Fadaei, Reza; Tahmasian, Masoud; Khazaie, Habibolah; Zarei, Mojtaba

doi:10.1007/s11682-021-00512-w

Cited by 5 publications

(6 citation statements)

References 47 publications

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“…Previous studies suggested that structural alterations in the cingulum were associated with sleep disturbances and insomnia. 14,31 We speculate that structural changes in the cingulum caused by shift work induce sleep disturbances. Additionally, the anterior cingulum has been suggested to participate in cognitive and memory functions 32 as well as emotional processing (as a component of the Papez circuit).…”

Section: Discussionmentioning

confidence: 93%

“…Higher white matter integrity in the cingulum has been associated with poor sleep quality in insomniacs. 14 Another possible explanation for the increased FA in shift workers (and the association thereof with sleep quality) is a circadian adaptation to shift work, which would be absent in non-shift workers. Functional changes in the cingulum were associated with recovery from jetlag, which can be interpreted as re-alignment after circadian disruption.…”

Section: Discussionmentioning

confidence: 99%

“…12,13 Shift workers are physically over-active during both occupational and non-occupational hours. 14,15 Previous studies have reported correlations between white matter integrity and physical activity; more physically active people evidenced more integrated white matter. 16,17 Therefore, we investigated whether sleep quality and the activity level were associated with white matter alterations in shift workers.…”

Section: Introductionmentioning

confidence: 98%

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Evidence of White Matter Integrity Changes in the Anterior Cingulum Among Shift Workers: A Cross-Sectional Study

Lee¹,

Kim²,

Kim³

et al. 2022

NSS

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Introduction We investigated the white matter integrity in shift and non-shift workers and its associations with sleep and activity. Methods Diffusion tensor imaging (DTI) was performed on 61 shift workers and 31 non-shift workers. Their sleep and activity profiles were assessed using the Pittsburgh Sleep Quality Index (PSQI), sleep diaries, and actigraphy. Fractional anisotropy (FA) (a measure of white matter integrity) was calculated using DTI tractography. Results Shift workers exhibited higher FA values in the bilateral anterior cingulum than did non-shift workers. An increased FA in the right anterior cingulum was correlated with poor sleep quality (ie, a high PSQI score) in shift workers. An increased FA in the right anterior cingulum was also correlated with higher actigraphic activity indices (the mesor and M10 indices) in shift workers. Discussion The white matter integrity of the anterior cingulum was altered in shift workers, perhaps in association with sleep and activity disturbances.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

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Evidence of White Matter Integrity Changes in the Anterior Cingulum Among Shift Workers: A Cross-Sectional Study

Lee¹,

Kim²,

Kim³

et al. 2022

NSS

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“…The increased FA value in the left CAB region in MDD patients is in line with the findings from previous studies in patients with treatment-resistant depression, 30 posttraumatic stress disorder, 31 and insomnia. 32 The CAB directly connects the posterior cingulate cortex and subiculum of the hippocampus, 33,34 both of which are part of the default mode network, which is altered in MDD. [35][36][37][38] Furthermore, the integrity of the CAB is associated with decision-making, episodic memory, and executive control.…”

Section: Discussionmentioning

confidence: 99%

Association Between the C4 Binding Protein Level and White Matter Integrity in Major Depressive Disorder

Park¹,

Kang²,

Han³

et al. 2022

Psychiatry Investig

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Objective Considerable evidence suggests that neuroinflammation plays an important role in the pathophysiology of major depressive disorder (MDD). However, the relationship between serum C4 binding protein (C4BP) and white matter (WM) tract integrity in MDD has not been investigated.Methods We obtained diffusion tensor images of 44 patients with MDD and 44 healthy controls and performed TRActs Constrained by UnderLying Anatomy (TRACULA) analysis to assess WM tract integrity. Serum C4-binding protein alpha chain (C4BPA) and C4- binding protein beta chain (C4BPB) levels were measured and in-between group comparisons were obtained. The correlation between serum C4BP levels and WM tract integrity was examined.Results In comparison to healthy controls, both serum C4BPA and C4BPB were higher in MDD. Also, fractional anisotropy (FA) was increased in the left cingulum-angular bundle (CAB) in MDD, but not healthy controls (HCs). A significant correlation was found between serum C4BP and FA levels in the right cingulum-cingulate gyrus bundle (CCG) in MDD.Conclusion This study is the first to investigate the correlation between serum C4BP levels and WM tract integrity in MDD. We identified an increase in WM integrity in the left CAB region in MDD. Furthermore, serum C4BP levels were higher in MDD, and this finding correlated with increased WM integrity in the right CCG region.

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“… Yu et al (2020) found that the severity of insomnia in PI patients directly correlates with the thicknesses of the cortex of the right orbital frontal lobe and the right fusiform area, indicating that the thickening of the cortex, especially the right cortex, maybe the neuropathological basis of PI. Rostampour et al (2022) found that PI patients had asymmetrical, extensive white matter integrity changes in the two cerebral hemispheres, which was conducive to the diagnosis and prognosis of PI. These studies focused on the changes in brain volume and morphology in patients with insomnia.…”

Section: Introductionmentioning

confidence: 94%

Quantitative association of cerebral blood flow, relaxation times and proton density in young and middle-aged primary insomnia patients: A prospective study using three-dimensional arterial spin labeling and synthetic magnetic resonance imaging

Luo

Shen

et al. 2023

Front. Neurosci.

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ObjectivesTo quantitatively measure the T1 value, T2 value, proton density (PD) value, and cerebral blood flow (CBF) in young and middle-aged primary insomnia (PI) patients, and analyze the correlations between relaxation times, PD, and CBF to explore potential brain changes.MethodsCranial magnetic resonance (MR) images of 44 PI patients and 30 healthy subjects were prospectively collected for analysis. The T1, T2, PD, and CBF values of the frontal lobe, parietal lobe, temporal lobe, and occipital lobe were independently measured using three-dimensional arterial spin labeling (3D-ASL), synthetic magnetic resonance imaging (syMRI) and a whole-brain automatic segmentation method. The differences of these imaging indices were compared between PI patients and healthy subjects. Follow-up MR images were obtained from PI patients after 6 months to compare with pre-treatment images. The Wilcoxon signed rank test and Spearman rank were used for statistical analysis.ResultsBilateral CBF asymmetry was observed in 38 patients, with significant differences in both the T2 value and CBF between the four lobes of the brain (p < 0.01). However, no significant difference was found in the T1 and PD values between the bilateral lobes. A negative correlation was found between CBF and T2 values in the right four lobes of patients with primary insomnia (PI). During follow-up examinations, five PI patients showed a disappearance of insomnia symptoms and a decrease in CBF in both brain lobes.ConclusionInsomnia symptoms may be associated with high CBF, and most PI patients have higher CBF and lower T2 values in the right cerebral hemispheres. The right hemisphere appears to play a critical role in the pathophysiology of PI. The 3D-ASL and syMRI technologies can provide a quantitative imaging basis for investigating the brain conditions and changes in young and middle-aged PI patients.

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Asymmetric alterations of white matter integrity in patients with insomnia disorder

Cited by 5 publications

References 47 publications

Evidence of White Matter Integrity Changes in the Anterior Cingulum Among Shift Workers: A Cross-Sectional Study

Evidence of White Matter Integrity Changes in the Anterior Cingulum Among Shift Workers: A Cross-Sectional Study

Association Between the C4 Binding Protein Level and White Matter Integrity in Major Depressive Disorder

Quantitative association of cerebral blood flow, relaxation times and proton density in young and middle-aged primary insomnia patients: A prospective study using three-dimensional arterial spin labeling and synthetic magnetic resonance imaging

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