Background:
Some patients with hypertrophic obstructive cardiomyopathy
(HOCM) still exhibit systolic anterior motion (SAM) and mitral regurgitation (MR)
even after undergoing an isolated ventricular septectomy. Currently, there are
disputes regarding whether to perform a mitral valve intervention and which type
of operation is more effective.
Methods:
By searching PubMed, Cochrane,
Embase, Web of Science, FDA.gov, and ClinicalTrials.gov, as well as other
resource databases, we obtained all articles published before December 2022 on
ventricular septal myectomy combined with mitral valve intervention for
hypertrophic cardiomyopathy. Demographic information and outcome variable data
were extracted from 10 screened studies on ventricular septal resection combined
with mitral valve repair. The risk of bias was assessed using methodological
index for non-randomized studies (MINORS). Student’s
t
-test was used for
comparisons of continuous variables, and the chi-square or Fisher’s exact test
was used for dichotomous variables. A total of 692 patients across 10 studies
were analyzed.
Results:
There were 5 (0.7%) deaths in the perioperative
period. The average cardiopulmonary bypass time was 64.7
22.2 minutes,
and the average follow-up time was 39.6
36.3 months. Compared with
baseline levels, the left ventricular outflow tract gradient (83.6
32.2
mmHg vs. 11.0
7.8 mmHg,
p
0.01), maximum interventricular
septal thickness (22.5
5.1 mm vs. 14.7
5.5 mm,
p
0.01), III/IV mitral regurgitation (351/692 vs. 17/675,
p
0.01),
anterior mitral leaflet (AML)-annulus ratio (0.49
0.14 vs. 0.60
0.12,
p
0.01), tenting area (2.72
0.60
vs. 1.95
0.60
,
p
0.01), and SAM (181/194 vs. 11/215,
p
0.01) were significantly improved. 14 (2.1%) patients were in New York
Heart Association functional class III/IV, which was significantly improved
compared with the preoperative state (541/692 vs. 14/682,
p
0.01).
Conclusions:
Ventricular septectomy combined with mitral valve repair
can be a safe and effective treatment option for patients suffering from HOCM
with SAM and severe MR.