2021
DOI: 10.1016/j.neurobiolaging.2021.02.012
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Astrogliosis and episodic memory in late life: higher GFAP is related to worse memory and white matter microstructure in healthy aging and Alzheimer's disease

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Cited by 35 publications
(45 citation statements)
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“…Epidemiological studies suggest that elevated immune biomarkers in the blood may be evident years prior to the manifestation of clinical symptoms of AD or AD-related dementias (ADRDs) in the typical population (Schmidt et al, 2002 ; Ridolfi et al, 2013 ; Leszek et al, 2016 ; Busse et al, 2017 ; Wendeln et al, 2018 ). Higher plasma levels of GFAP are correlated with lower measures of episodic memory and microstructural integrity in AD, MCI, and also in healthy aged donors (Bettcher et al, 2021 ). As discussed, people with DS also have increasing levels of plasma GFAP starting in their mid-40s (Hendrix et al, 2021 ).…”
Section: Introductionmentioning
confidence: 99%
“…Epidemiological studies suggest that elevated immune biomarkers in the blood may be evident years prior to the manifestation of clinical symptoms of AD or AD-related dementias (ADRDs) in the typical population (Schmidt et al, 2002 ; Ridolfi et al, 2013 ; Leszek et al, 2016 ; Busse et al, 2017 ; Wendeln et al, 2018 ). Higher plasma levels of GFAP are correlated with lower measures of episodic memory and microstructural integrity in AD, MCI, and also in healthy aged donors (Bettcher et al, 2021 ). As discussed, people with DS also have increasing levels of plasma GFAP starting in their mid-40s (Hendrix et al, 2021 ).…”
Section: Introductionmentioning
confidence: 99%
“…Mutations in GFAP lead to Alexander disease, a genetic disorder characterized by fibrinoid degeneration of astrocytes, demyelination and white matter anomalies 64 . GFAP variations have also been associated with white matter microstructure phenotypes and Alzheimer’s disease 57, 65, 66 . While astrocytes are present in both grey and white matter, GFAP expression is higher in white matter astrocytes than in grey matter astrocytes 67 .…”
Section: Resultsmentioning
confidence: 99%
“…The early phases of AD are characterized by a gradual decline in neurocognitive functions including impairments in episodic and semantic memory and word fluency [5,6] . In the later stages of AD, patients suffer from deficits in memory, language and naming, orientation, executive functions, perceptual-motor functions, attention, and social skills including communication and judgement [6,7] . At that stage, difficulties to perform activities of daily living (ADL) and neuropsychiatric symptoms, such as behavioral dysregulation, irritability and aggression, inertia, and depressive, vegetative, and psychotic symptoms may be evident [7] .…”
Section: Introductionmentioning
confidence: 99%
“…In the later stages of AD, patients suffer from deficits in memory, language and naming, orientation, executive functions, perceptual-motor functions, attention, and social skills including communication and judgement [6,7] . At that stage, difficulties to perform activities of daily living (ADL) and neuropsychiatric symptoms, such as behavioral dysregulation, irritability and aggression, inertia, and depressive, vegetative, and psychotic symptoms may be evident [7] . The pathophysiology of AD comprises neuroinflammation with astrogliosis, neurofibrillary tangles, accumulation of amyloid plaques, dystrophic neurites with tau protein, and synaptic, neuronal, and neuropil loss [2,3,8,9] .…”
Section: Introductionmentioning
confidence: 99%