Astrocytic growth through the autocrine/paracrine production of IL-1β in the early infectious phase of fowl glioma-inducing virus

Nakamura, Shigeto; Ochiai, Kenji; Abe, Asumi; Kishi, Sayaka; Takayama, Koh; Sunden, Yuji

doi:10.1080/03079457.2014.952621

Cited by 3 publications

(2 citation statements)

References 34 publications

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“…However, the overproduction of IL-1β has been implicated in the pathophysiological changes that occur during different disease states, such as rheumatoid arthritis, vascular disease, multiple sclerosis, AD, and PD [3]. In the central nervous system (CNS), IL-1β can be released from various types of cells, including Schwann cells, microglia, and astrocytes [6,7]. Upon binding to IL-1 receptors, IL-1β activates the sequential phosphorylation of protein kinases, such as platelet-derived growth factor receptor (PDGFR), Pyk2, c-Src, phosphoinositide 3-kinase (PI3K)/Akt, and mitogen-activated protein kinases (MAPKs), and nuclear factor κB (NF-κB) signaling, which leads to the expression of various target genes by transcriptional and posttranscriptional mechanisms [8,9].…”

Section: Introductionmentioning

confidence: 99%

RTA 408 Inhibits Interleukin-1β-Induced MMP-9 Expression via Suppressing Protein Kinase-Dependent NF-κB and AP-1 Activation in Rat Brain Astrocytes

Yang

Lin

Jou

et al. 2019

IJMS

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Neuroinflammation is characterized by the elevated expression of various inflammatory proteins, including matrix metalloproteinases (MMPs), induced by various pro-inflammatory mediators, which play a critical role in neurodegenerative disorders. Interleukin-1β (IL-1β) has been shown to induce the upregulation of MMP-9 through nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX)-reactive oxygen species (ROS)-dependent signaling pathways. N-(2-cyano-3,12-dioxo-28-noroleana-1,9(11)-dien-17-yl)-2-2-difluoropropanamide (RTA 408), a novel synthetic triterpenoid, has been shown to possess anti-oxidant and anti-inflammatory properties in various types of cells. Here, we evaluated the effects of RTA 408 on IL-1β-induced inflammatory responses by suppressing MMP-9 expression in a rat brain astrocyte (RBA-1) line. IL-1β-induced MMP-9 protein and mRNA expression, and promoter activity were attenuated by RTA 408. The increased level of ROS generation in RBA-1 cells exposed to IL-1β was attenuated by RTA 408, as determined by using 2′,7′-dichlorodihydrofluorescein diacetate (DCFH-DA) and CellROX. In addition, the inhibitory effects of RTA 408 on MMP-9 expression resulted from the suppression of the IL-1β-stimulated activation of Pyk2 (proline-rich tyrosine kinase), platelet-derived growth factor receptor β (PDGFRβ), Akt, ROS, and mitogen-activated protein kinases (MAPKs). Pretreatment with RTA 408 attenuated the IL-1β-induced c-Jun phosphorylation, mRNA expression, and promoter activity. IL-1β-stimulated nuclear factor-κB (NF-κB) p65 phosphorylation, translocation, and promoter activity were also attenuated by RTA 408. Furthermore, IL-1β-induced glial fibrillary acidic protein (GFAP) protein and mRNA expression, and cell migration were attenuated by pretreatment with RTA 408. These results provide new insights into the mechanisms by which RTA 408 attenuates IL-1β-mediated inflammatory responses and exerts beneficial effects for the management of brain diseases.

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Section: Introductionmentioning

confidence: 99%

RTA 408 Inhibits Interleukin-1β-Induced MMP-9 Expression via Suppressing Protein Kinase-Dependent NF-κB and AP-1 Activation in Rat Brain Astrocytes

Yang

Lin

Jou

et al. 2019

IJMS

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“…From these, ALV-A and ALV-J are the most prevalent while the others are scarce in comparison [15,42], though ALV-K and recombinants are not rare in some populations [20,43]. ALV-A and ALV-B are recognized as the classic and common pathogenic exogenous viruses that induce lymphoid leukosis, erythroblastosis [44,45], as well as glioma development [46] in chickens. Subgroups C and D have been reported rarely in the field (reviewed in [47]), and there is little research in which they are characterized, besides the receptor they use for cell entry, quite opposite to the situation of ALV-J, which has received the most attention in recent years.…”

Section: Exogenous Alv Subgroupsmentioning

confidence: 99%

Avian Leukosis: Will We Be Able to Get Rid of It?

Fandiño,

Gomez-Lucia,

Benítez

et al. 2023

Animals

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Avian leukosis viruses (ALVs) have been virtually eradicated from commercial poultry. However, some niches remain as pockets from which this group of viruses may reemerge and induce economic losses. Such is the case of fancy, hobby, backyard chickens and indigenous or native breeds, which are not as strictly inspected as commercial poultry and which have been found to harbor ALVs. In addition, the genome of both poultry and of several gamebird species contain endogenous retroviral sequences. Circumstances that support keeping up surveillance include the detection of several ALV natural recombinants between exogenous and endogenous ALV-related sequences which, combined with the well-known ability of retroviruses to mutate, facilitate the emergence of escape mutants. The subgroup most prevalent nowadays, ALV-J, has emerged as a multi-recombinant which uses a different receptor from the previously known subgroups, greatly increasing its cell tropism and pathogenicity and making it more transmissible. In this review we describe the ALVs, their different subgroups and which receptor they use to infect the cell, their routes of transmission and their presence in different bird collectivities, and the immune response against them. We analyze the different systems to control them, from vaccination to the progress made editing the bird genome to generate mutated ALV receptors or selecting certain haplotypes.

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