Astrocytes Modulate the Polarization of CD4+ T Cells to Th1 Cells

Beurel, Eléonore; Harrington, Laurie E.; Buchser, William J.; Lemmon, Vance; Jope, Richard S.

doi:10.1371/journal.pone.0086257

Cited by 35 publications

(28 citation statements)

References 51 publications

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“…Expression of three different iGluRs has also been shown on CD4+ T-cells, and their stimulation potentiates activation-induced intracellular calcium mobilization (Lombardi et al 2001). In line with previous results, a recent study has shown that NMDA receptor stimulation on CD4+ Tcells enhances Tbet expression and potentiates IFN-γ production (Beurel et al 2014). Thus, elevated glu levels on PD brain could lead to a neuroinflammatory phenotype on CD4+ T-cells.…”

Section: Neurotransmitters As Modulators Of Encephalitogenic T-cells supporting

confidence: 89%

Regulation of the Neurodegenerative Process Associated to Parkinson’s Disease by CD4+ T-cells

González

Contreras

Pacheco

2015

J Neuroimmune Pharmacol

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Neuroinflammation constitutes a fundamental process involved in the physiopathology of Parkinson's disease (PD). Microglial cells play a central role in the outcome of neuroinflammation and consequent neurodegeneration of dopaminergic neurons in the substantia nigra. Current evidence indicates that CD4+ T-cells infiltrate the central nervous system (CNS) in PD, where they play a critical role determining the functional phenotype of microglia, thus regulating the progression of the neurodegenerative process. Here, we first analysed the pathogenic role of inflammatory phenotypes and the beneficial role of anti-inflammatory phenotypes of encephalitogenic CD4+ T-cells involved in the physiopathology of PD. Next, we discussed how alterations of neurotransmitter levels observed in the basal ganglia throughout the time course of PD progression could be strongly affecting the behaviour of encephalitogenic CD4+ T-cells and thereby the outcome of the neuroinflammatory process and the consequent neurodegeneration of dopaminergic neurons. Afterward, we integrated the evidence indicating the involvement of an antigen-specific immune response mediated by T-cells and B-cells against CNS-derived self-constituents in PD. Consistent with the involvement of a relevant autoimmune component in PD, we also reviewed the polymorphisms of both, class I and class II major histocompatibility complexes, associated to the risk of PD. Overall, this study gives an overview of how an autoimmune component involved in PD plays a fundamental role in the progression of the neurodegenerative process.

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Section: Neurotransmitters As Modulators Of Encephalitogenic T-cells supporting

confidence: 89%

Regulation of the Neurodegenerative Process Associated to Parkinson’s Disease by CD4+ T-cells

González

Contreras

Pacheco

2015

J Neuroimmune Pharmacol

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“…Similarly, aligned electrospun nanofibers minimize the host immune reaction, enhance tissue-scaffold integration, and generate a thinner fibrous capsule compared to random fibers and films [32]. Diameter of electrospun fibers modulate the immune reaction, macrophage-mediated release of pro-inflammatory cytokines, and astrocyte-mediated reduction of excitotoxic glutamate [31, 36], the latter of which could promote Treg infiltration and prevent chronic inflammation [37]. …”

Section: 1 Biomaterialsmentioning

confidence: 99%

Controlled release strategies for modulating immune responses to promote tissue regeneration

Park

Shea

2015

Journal of Controlled Release

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Advances in the field of tissue engineering have enhanced the potential of regenerative medicine, yet the efficacy of these strategies remains incomplete, and is limited by the innate and adaptive immune responses. The immune response associated with injury or disease combined with that mounted to biomaterials, transplanted cells, proteins, and gene therapies vectors can contribute to the inability to fully restore tissue function. Blocking immune responses such as with anti-inflammatory or immunosuppressive agents are either ineffective, as the immune response contributes significantly to regeneration, or have significant side effects. This review describes targeted strategies to modulate the immune response in order to limit tissue damage following injury, promote an anti-inflammatory environment that leads to regeneration, and induce antigen (Ag)-specific tolerance that can target degenerative diseases that destroy tissues and promote engraftment of transplanted cells. Focusing on targeted immuno-modulation, we describe local delivery techniques to sites of inflammation as well as systemic approaches that preferentially target subsets of immune populations.

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“…Recent in vitro studies provided clues of the effect of astrocytes on T cells. Eléonore Beure et al found that culturing mouse CD4 + T-cells on mouse primary astrocytes without supplements of additional cytokines modified T-cell polarization to Th1 and Treg subtypes (Beurel et al, 2014). This modified T-cell polarization was diminished by inflammatory activation of astrocytes.…”

Section: Interaction Between Astrocytes and T Cells Under Physiolomentioning

confidence: 99%

“…Besides IL-2, astrocytes might affect T cells via other mechanisms. For example, glutamate promotes Th1 cell production in the presence of anti-IL-4 and IL-12 (Beurel et al, 2014). Addition of glutamate on CD4 + T cells was sufficient to increase T-bet expression.…”

Section: Interaction Between Astrocytes and T Cells Under Physiolomentioning

confidence: 99%

Interaction of astrocytes and T cells in physiological and pathological conditions

Xie

Yang

2015

Brain Research

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The central nervous system (CNS) has long been recognized as a site of ‘immune privilege’ because of the existence of the blood brain barrier (BBB) which presumably isolates CNS from the peripheral immunosurveillance. Different from the peripheral organs, CNS is unique in response to all forms of CNS injury and disease which is mainly mediated by resident microglia and astrocyte. There is increasing evidence that immune cells are not only involved in neuroinflammation process but also the maintenance of CNS homeostasis. T cells, an important immune cell population, are involved in the pathogenesis of some neurological diseases by inducing either innate or adaptive immune responses. Astrocytes, which are the most abundant cell type in the CNS, maintain the integrity of BBB and actively participate in the initiation and progression of neurological diseases. Surprisingly, how astrocytes and T cells interact and the consequences of their interaction are not clear. In this review we briefly summarized T cells diversity and astrocyte function. Then, we examined the evidence for the astrocytes and T cells interaction under physiological and pathological conditions including ischemic stroke, multiple sclerosis, viral infection, and Alzheimer’s disease.

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Astrocytes Modulate the Polarization of CD4+ T Cells to Th1 Cells

Cited by 35 publications

References 51 publications

Regulation of the Neurodegenerative Process Associated to Parkinson’s Disease by CD4+ T-cells

Regulation of the Neurodegenerative Process Associated to Parkinson’s Disease by CD4+ T-cells

Controlled release strategies for modulating immune responses to promote tissue regeneration

Interaction of astrocytes and T cells in physiological and pathological conditions

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