Astrocytes, Metabolism, Signaling and Brain Drains: Introduction to the Special Issue in Honor of Gerald Dienel

Rae, Caroline; Sonnewald, Ursula

doi:10.1007/s11064-015-1781-0

Cited by 2 publications

(3 citation statements)

References 13 publications

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“…It induces anaerobic metabolism mechanisms, elevated lactate, calcium overload, and declined mitochondrial function, leading to lipid membrane destruction and umbra and penumbra neuron cell death. 55,56 There is no significant difference in diabetic and non-diabetic ischemic stroke patient outcomes. 57 Diabetic hyperglycemia is proven by a history of diabetes diagnosis, a positive fasting blood glucose examination, and an oral glucose tolerance test.…”

Section: Discussionmentioning

confidence: 98%

Age-Associated with Worsening of Neurological Deficits in Ischemic Stroke Patients in Abdoel Wahab Sjahranie Regional Hospital, Samarinda

Indria,

Rachmi,

Hutahaean

2024

JUXTA

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Highlights: The worsening of neurological deficits in ischemic stroke patients is associated with the patient’s age, with those over 45 years old having a higher risk. The worsening of neurological deficits in ischemic stroke patients does not correlate with hemoglobin level, hematocrit value, gender, smoking history, blood pressure, or hyperglycemic state. Abstract Introduction: Treatment of impairment is an important step to prevent advanced neurological deficits in ischemic stroke medicine. Ischemic stroke patients with likely worsening neurological deficits should receive appropriate interventions. Therefore, this study aimed to examine predictors that can identify worsening neurological deficits. Methods: This study used a cross-sectional design on 74 hospitalized ischemic stroke patients at Abdoel Wahab Sjahranie Regional Hospital, Samarinda. The worsening of neurological deficits was based on the progression of the National Institutes of Health Stroke Scale (NIHSS) scores at hospital admission and discharge. Age (p = 0.024), hemoglobin level, hematocrit value, gender, smoking history, blood pressure, and hyperglycemic state (p = 0.05) were based on patient data at the beginning of hospital admission. The Chi-Square and Fisher’s exact tests were used in bivariate analysis. Results: The results showed that age had a significant association with the worsening of neurological deficits in ischemic stroke patients (p = 0.024). Hemoglobin level, hematocrit value, gender, smoking history, blood pressure, and hyperglycemic state showed no relationship with worsening neurological deficits in ischemic stroke patients (p > 0.05). Conclusion: Age can serve as a predictor of worsening neurological deficits in ischemic stroke patients, with those aged over 45 years old having a higher risk. Meanwhile, the other factors were not associated with a worsening neurological deficit in ischemic stroke patients.

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Section: Discussionmentioning

confidence: 98%

Age-Associated with Worsening of Neurological Deficits in Ischemic Stroke Patients in Abdoel Wahab Sjahranie Regional Hospital, Samarinda

Indria,

Rachmi,

Hutahaean

2024

JUXTA

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“…Glutamate, aspartate, and lactate are central to brain metabolism, playing crucial roles in supporting physiological functions critical for cognitive processes 37,38,61 . These metabolites, interconnected through the tricarboxylic acid (TCA) cycle and glycolysis (see Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Proton ( 1 H)-MRS enables the quantification of several brain metabolites, such as glutamate, lactate, aspartate, N-acetylaspartate (NAA), creatine, and others. These metabolites play crucial roles in neuronal health, energy metabolism, and cellular signaling, all key for neural function and behavior production [36][37][38] . Understanding whether the concentrations of these metabolites in key brain regions are related to effort-based motivated processes can provide invaluable insights into the neurometabolic foundations of these cognitive functions.…”

Section: Introductionmentioning

confidence: 99%

A neurometabolic signature in the frontal cortex explains individual differences in effort-based decision-making

Barakat,

Clairis,

Brochard

et al. 2024

Preprint

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Exploring why individuals vary in their willingness to exert effort in decision-making is fundamental for understanding human behavior. Our study focuses on the dorsomedial prefrontal cortex/dorsal anterior cingulate cortex (dmPFC/dACC), a crucial brain region in motivation and decision-making, to uncover the neurobiological factors influencing these individual differences. We utilized 7T proton magnetic resonance spectroscopy (1H-MRS) to analyze metabolite concentrations in the dmPFC/dACC and anterior insula (AI) of 75 participants, aiming to predict individual variability in effort-based decision-making. Employing computational modeling, we identified key motivational parameters and, using machine learning models, pinpointed glutamate, aspartate, and lactate as crucial metabolites predicting decision-making to exert high mental effort, signifying their role as potential biomarkers for mental effort decision-making. Additionally, we examined the relationships between plasma and brain metabolite concentrations. Our findings provide novel insights into the neurometabolic underpinnings of motivated behavior, offering new perspectives in the field of cognitive neuroscience and human behavior.

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Astrocytes, Metabolism, Signaling and Brain Drains: Introduction to the Special Issue in Honor of Gerald Dienel

Cited by 2 publications

References 13 publications

Age-Associated with Worsening of Neurological Deficits in Ischemic Stroke Patients in Abdoel Wahab Sjahranie Regional Hospital, Samarinda

Age-Associated with Worsening of Neurological Deficits in Ischemic Stroke Patients in Abdoel Wahab Sjahranie Regional Hospital, Samarinda

A neurometabolic signature in the frontal cortex explains individual differences in effort-based decision-making

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