2000
DOI: 10.1016/s0306-4522(00)00051-8
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Astrocytes in sensory circumventricular organs of the rat brain express functional binding sites for endothelin

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Cited by 23 publications
(18 citation statements)
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“…For example, increased ET-1 levels during acute pneumococcal sepsis promote meningitis through vasoconstriction, resulting in cerebral ischemia (81,83). Brain endothelial cells, microglia, astrocytes, and neurons are other sources of ET-1 (78,84). We observed endogenous secretion levels comparable to those found in DH82 cells by Divino et al (37), but we did not observe the reported stimulation with LPS.…”
Section: Discussioncontrasting
confidence: 41%
“…For example, increased ET-1 levels during acute pneumococcal sepsis promote meningitis through vasoconstriction, resulting in cerebral ischemia (81,83). Brain endothelial cells, microglia, astrocytes, and neurons are other sources of ET-1 (78,84). We observed endogenous secretion levels comparable to those found in DH82 cells by Divino et al (37), but we did not observe the reported stimulation with LPS.…”
Section: Discussioncontrasting
confidence: 41%
“…A type of sodium channel involved in the detection of this ion has been described in the glial cells of the SFO (Noda 2007), and is known to be activated by endothelin-3 (Noda and Sakuta 2013). Endothelin distribution also forms a shell in its co-localization with GFAP (Gebke et al 2000). Hence, the different glio-vascular structures in the core and shell may serve different detection functions (peptides versus small molecules and osmoperception).…”
Section: Aquaporin 4: Correlation With Gfap and Osmometric Functionmentioning
confidence: 99%
“…In the CNS, the ET system influences fluid and electrolyte homeostasis, cardiovascular functions, and neurosecretion (Stoljilkovic and Catt 1998). Endothelins and their receptors have been detected in glial cells (MacCumber et al 1990;Gebke et al 2000), neurons (Giaid et al 1991), and brain endothelial cells (Giaid et al 1991;McCarron et al 2006). ET1-and ET3-like peptides and ETA and ETB receptors are expressed in astrocytes of the rat organum vasculosum of the lamina terminalis and the subfornical organ (Gebke et al 2000).…”
Section: Introductionmentioning
confidence: 99%