Astrocytes control quiescent NSC reactivation via GPCR signaling-mediated F-actin remodeling
Kun-Yang Lin,
Mahekta R. Gujar,
Jiaen Lin
et al.
Abstract:The transitioning of neural stem cells (NSCs) between quiescent and proliferative states is fundamental for brain development and homeostasis. Defects in NSC reactivation are associated with neurodevelopmental disorders.Drosophilaquiescent NSCs extend an actin-rich primary protrusion toward the neuropil. However, the function of the actin cytoskeleton during NSC reactivation is unknown. Here, we reveal the fine F-actin structures in the protrusions of quiescent NSCs by expansion and super-resolution microscopy… Show more
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