Astrocytes and Chronic Pain Mechanisms—The Role of Histamine, IL-1β and NGF

Lipnik‐Štangelj, Metoda; Surcheva, Slavina; Ferjan, I.; Vlaskovska, Mila

doi:10.5504/bbeq.2012.0117

Cited by 2 publications

(2 citation statements)

References 27 publications

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“…Surprisingly, we did not observe nerve growth factor (NGF) production in astrocyte cultures in either one- or six-day stimulations at ELISA detection level (data not shown), although astrocytes are considered major producers of this neurotrophic factor [ 93 ]. Metoda et al described the role of histamine together with IL-1β in the induction of NGF production in cortical astrocytes from rats [ 94 ]. Another inducer of NGF is IFN-β, which was able to induce a 40-fold increase in mRNA for NGF [ 95 ].…”

Section: Discussionmentioning

confidence: 99%

Human Primary Astrocytes Differently Respond to Pro- and Anti-Inflammatory Stimuli

et al. 2022

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For a long time, astrocytes were considered a passive brain cell population. However, recently, many studies have shown that their role in the central nervous system (CNS) is more active. Previously, it was stated that there are two main functional phenotypes of astrocytes. However, nowadays, it is clear that there is rather a broad spectrum of these phenotypes. The major goal of this study was to evaluate the production of some inflammatory chemokines and neurotrophic factors by primary human astrocytes after pro- or anti-inflammatory stimulation. We observed that only astrocytes induced by inflammatory mediators TNFα/IL-1a/C1q produced CXCL10, CCL1, and CXCL13 chemokines. Unstimulated astrocytes and those cultured with anti-inflammatory cytokines (IL-4, IL-10, or TGF-β1) did not produce these chemokines. Interestingly, astrocytes cultured in proinflammatory conditions significantly decreased the release of neurotrophic factor PDGF-A, as compared to unstimulated astrocytes. However, in response to anti-inflammatory cytokine TGF-β1, astrocytes significantly increased PDGF-A production compared to the medium alone. The production of another studied neurotrophic factor BDNF was not influenced by pro- or anti-inflammatory stimulation. The secretory response was accompanied by changes in HLA-DR, CD83, and GFAP expression. Our study confirms that astrocytes differentially respond to pro- and anti-inflammatory stimuli, especially to inflammatory cytokines TNF-α, IL-1a, and C1q, suggesting their role in leukocyte recruitment.

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Section: Discussionmentioning

confidence: 99%

Human Primary Astrocytes Differently Respond to Pro- and Anti-Inflammatory Stimuli

et al. 2022

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“…As a major factor in allergic diseases, histamine is present in cytoplasmic granules of human basophilic granulocytes and mast cells ( Yasuda et al, 2019 ), and exists in extracellular regions of the epidermis ( Paivandy and Pejler, 2021 ). When allergic reaction occurs in tissues, it will cause the rupture of basophilic granulocytes and mast cells to release histamine, and induce keratinocytes to secrete inflammatory cytokines IL-1β and NGF ( Lipnik-Stangelj et al, 2013 ). In addition, it will also cause dilation of capillaries and venules and increase permeability of tube walls, smooth muscle spasm, and enhancement of glandular secretion activities, resulting in local skin tissue showing congestion, erythema, and swelling ( Maria Arin et al, 2017 ; Gao et al, 2018 ; Yamamoto et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Tea for histamine anti-allergy: component analysis of tea extracts and potential mechanism for treating histamine anti-allergy

Huang,

Zhang,

Xuan

et al. 2024

Front. Pharmacol.

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In China, Camellia plants are widely used to reduce atopic dermatitis and inflammation-related diseases, but their protective mechanisms remain unclear. This study investigated the anti-allergic dermatitis, anti-oxidation and anti-inflammation effect and underlying mechanism of five Camellia species, including Camellia ptilophylla Chang, Camellia assamica Chang var. Kucha Chang, Camellia parvisepala Chang, Camellia arborescens Chang, and C. assamica M. Chang. A total of about 110 chemical compositions were detected from five Camellia teas extracts. The level of mast cell infiltration in the model mice skin was determined by HE (Hematoxylin and eosin) staining and toluidine blue staining, and the level of interleukin-1β (IL-1β) and nerve growth factor was detected by immunohistochemistry. The five Camellia tea leaf extracts have histamine-induced allergic dermatitis. Lipopolysaccharide (Lipopolysaccharide)-induced murine macrophage RAW264.7 inflammation model was found to secrete NF-κB factor, as shown by immunofluorescence, and reactive oxygen species secretion and related cytokine levels were detected. The results suggested that Camellia’s five tea extracts had the ability to resist cellular oxidative stress. In addition, the results of cell inflammatory cytokines including fibronectin (FN) and interleukin-6 (IL-6) suggested that the five tea extracts of Camellia had anti-inflammatory effects. Therefore, it is suggested that five Camellia teas may possess inhibitory properties against allergic reactions, oxidative stress, and inflammation, and may prove beneficial in the treatment of allergies.

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Astrocytes and Chronic Pain Mechanisms—The Role of Histamine, IL-1β and NGF

Cited by 2 publications

References 27 publications

Human Primary Astrocytes Differently Respond to Pro- and Anti-Inflammatory Stimuli

Human Primary Astrocytes Differently Respond to Pro- and Anti-Inflammatory Stimuli

Tea for histamine anti-allergy: component analysis of tea extracts and potential mechanism for treating histamine anti-allergy

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