Astrocyte-neuron interaction in diphenyl ditelluride toxicity directed to the cytoskeleton

Heimfarth, Luana; Ferreira, Fernanda da Silva; Pierozan, Paula; Mingori, Moara Rodrigues; Moreira, José Cláudio Fonseca; Rocha, João Batista Teixeira da; Pessoa-Pureur, Regina

doi:10.1016/j.tox.2017.01.015

Cited by 11 publications

(5 citation statements)

References 56 publications

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“…However, targets for this compound appear to be different according to the exposed cell type. Heimfarth et al showed DPDT-induced hyperphosphorylation of glial fibrillary acidic protein, vimentin, and neurofilament subunits from glial cells [79]. The authors reported that excessive Ca 2+ influx activated protein kinase A and protein kinase C in astrocytes, causing the hyperphosphorylation of glial fibrillary acidic protein and vimentin.…”

Section: Systems Biology and Signalingmentioning

confidence: 99%

Diphenyl Ditelluride: Redox-Modulating and Antiproliferative Properties

Trindade

Juchem

Guecheva

et al. 2019

Oxidative Medicine and Cellular Longevity

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Tellurium is a rare element that has been regarded as a toxic, nonessential element, and its biological role is not clearly established. In addition, the biological effects of elemental tellurium and some of its organic and inorganic derivatives have been studied, leading to a set of interesting and promising applications. Diphenyl ditelluride (DPDT), an organic tellurium derivate, showed antioxidant, antigenotoxic, antimutagenic, and anticancer properties. The antioxidant and prooxidant properties of DPDT are complex and depend on experimental conditions, which may explain the contradictory reports of these properties. In addition, DPDT may exert its effects through different pathways, including distinct ones to those responsible for chemotherapy resistance phenotypes: transcription factors, membrane receptors, adhesion, structural molecules, cell cycle regulatory components, and apoptosis pathways. This review aims to present recent advances in our understanding of the biological effects, therapeutic potential, and safety of DPDT treatment. Moreover, original results demonstrating the cytotoxic effects of DPDT in different mammalian cell lines and systems biology analysis are included, and emerging approaches for possible future applications are inferred.

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Section: Systems Biology and Signalingmentioning

confidence: 99%

Diphenyl Ditelluride: Redox-Modulating and Antiproliferative Properties

Trindade

Juchem

Guecheva

et al. 2019

Oxidative Medicine and Cellular Longevity

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“…Interesting studies about the toxicity of Ph 2 Te 2 are available in the literature [20,21,22,23,24]. However, the toxicological data on Ph 2 Te 2 and organotellurium compounds, in general, are not exhaustive and conflicting results were obtained, the majority of which lean towards the view that organotellurides have a higher toxicity compared to their selenium analogs [25].…”

Section: Introductionmentioning

confidence: 99%

The 125Te Chemical Shift of Diphenyl Ditelluride: Chasing Conformers over a Flat Energy Surface

et al. 2019

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The interest in diphenyl ditelluride (Ph2Te2) is related to its strict analogy to diphenyl diselenide (Ph2Se2), whose capacity to reduce organic peroxides is largely exploited in catalysis and green chemistry. Since the latter is also a promising candidate as an antioxidant drug and mimic of the ubiquitous enzyme glutathione peroxidase (GPx), the use of organotellurides in medicinal chemistry is gaining importance, despite the fact that tellurium has no recognized biological role and its toxicity must be cautiously pondered. Both Ph2Se2 and Ph2Te2 exhibit significant conformational freedom due to the softness of the inter-chalcogen and carbon–chalcogen bonds, preventing the existence of a unique structure in solution. Therefore, the accurate calculation of the NMR chemical shifts of these flexible molecules is not trivial. In this study, a detailed structural analysis of Ph2Te2 is carried out using a computational approach combining classical molecular dynamics and relativistic density functional theory methods. The goal is to establish how structural changes affect the electronic structure of diphenyl ditelluride, particularly the 125Te chemical shift.

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“…In order to complete the filtration of substances that enter the CNS through the plasma, some in vivo studies have shown (Sabourian et al, 2023) that a higher percentage of NPs are transfected into reactive astrocytes compared to neurons. The study by Heimfarth et al (2017) showed that astrocytes are more susceptible to the toxic effects of certain compounds than neurons, suggesting that different types of neuronal cells have different sensitivities to the same toxicants, and this aspect should be taken into account in the subsequent practical application of QDs. There were experimental proof that (Han et al, 2021; Luo et al, 2020; Zhu et al, 2020) QDs are able to enter and accumulate in astrocytes and their excellent luminescence properties enable the labeling of astrocytes (Maysinger et al, 2007), whether subsequent QDs will have toxic effects on astrocytes, and already whether subsequent indirect toxicity is worth further investigation.…”

Section: Factors Influencing Bbb Permeabilitymentioning

confidence: 99%

Exposure of quantum dots in the nervous system: Central nervous system risks and the blood–brain barrier interface

Guan,

Tang

2023

J of Applied Toxicology

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Quantum dots currently possess significant importance in the field of biomedical science. Upon introduction into the body, quantum dots exhibit a tendency to accumulate in diverse tissues including the central nervous system (CNS). Consequently, it becomes imperative to devote specific attention to their potential toxic effects. Moreover, the preservation of optimal CNS function relies heavily on blood–brain barrier (BBB) integrity, thereby necessitating its prioritization in neurotoxicological investigations. A more comprehensive understanding of the BBB and CNS characteristics, along with the underlying mechanisms that may contribute to neurotoxicity, will greatly aid researchers in the development of effective design strategies. This article offers an in‐depth look at the methods used to reduce the harmful effects of quantum dots on the nervous system, alongside the progression of effective treatments for brain‐related conditions. The focal point of this discussion is the BBB and its intricate association with the CNS and neurotoxicology. The discourse commences by recent advancements in the medical application of quantum dots are examined. Subsequently, elucidating the mechanisms through which quantum dots infiltrate the human body and traverse into the brain. Additionally, the discourse delves into the factors that facilitate the passage of quantum dots across the BBB, primarily encompassing the physicochemical properties of quantum dots and the BBB's inherent capacity for self‐permeability alteration. Furthermore, a concluding summary is presented, emphasizing existing research deficiencies and identifying promising avenues for further investigation within this field.

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Astrocyte-neuron interaction in diphenyl ditelluride toxicity directed to the cytoskeleton

Cited by 11 publications

References 56 publications

Diphenyl Ditelluride: Redox-Modulating and Antiproliferative Properties

Diphenyl Ditelluride: Redox-Modulating and Antiproliferative Properties

The 125Te Chemical Shift of Diphenyl Ditelluride: Chasing Conformers over a Flat Energy Surface

Exposure of quantum dots in the nervous system: Central nervous system risks and the blood–brain barrier interface

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