Astrocyte focal adhesion kinase reduces passive stress coping by inhibiting ciliary neurotrophic factor only in female mice

Jia, Cuihong; Gill, W. Drew; Lovins, Chiharu; Brown, Russell W.; Hagg, Theo

doi:10.1016/j.ynstr.2024.100621

Neurobiology of Stress

2024

DOI: 10.1016/j.ynstr.2024.100621

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Astrocyte focal adhesion kinase reduces passive stress coping by inhibiting ciliary neurotrophic factor only in female mice

Cuihong Jia,

W. Drew Gill,

Chiharu Lovins

et al.

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2024

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Ciliary neurotrophic factor as a potential biomarker of cerebral pathologies

Gudkova

2024

Nejrohimiâ

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Ciliary neurotrophic factor (CNTF) is a pluripotent neurotrophic factor with high neuroprotective potential, a neurocytokine that has demonstrated potential in the therapy of neurodegenerative, psychiatric and metabolic diseases. Preclinical data support the general concept of its potential neuroprotective and trophic effects, and recent clinical data support the potential role of CNTF in the treatment of neurodegeneration and obesity. A number of data indicate the involvement of CNTF in stress reactivity and the pathogenesis of affective disorders. Data from studies of CNTF levels in invasive (blood) and non-invasive (tears) human biomaterials suggest the possibility of its use as a biomarker for certain brain diseases, although more research is needed to confirm this.

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Ciliary neurotrophic factor as a potential biomarker of cerebral pathologies

Gudkova

2024

Nejrohimiâ

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Astrocyte focal adhesion kinase reduces passive stress coping by inhibiting ciliary neurotrophic factor only in female mice

Cited by 1 publication

References 88 publications

Ciliary neurotrophic factor as a potential biomarker of cerebral pathologies

Ciliary neurotrophic factor as a potential biomarker of cerebral pathologies

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