Astrocyte Calcium Signaling Transforms Cholinergic Modulation to Cortical Plasticity<i>In Vivo</i>

Takata, Norio; Mishima, Tatsuya; Hisatsune, Chihiro; Nagai, Torao; Ebisui, Etsuko; Mikoshiba, Katsuhiko; Hirase, Hajime

doi:10.1523/jneurosci.5289-11.2011

Cited by 344 publications

(365 citation statements)

References 68 publications

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“…ACh, a neuromodulator in the brain, changes the state of neuronal networks throughout the brain and modifies their response to internal and external inputs. Control of synaptic Ca 2+ concentration following nAChR stimulation is a major pathway for ACh to influence neuronal networks 36. Furthermore, nAChRs are also present in the cerebral vascular endothelium and smooth muscles 37.…”

Section: Discussionmentioning

confidence: 99%

Progressive brain changes in patients with chronic fatigue syndrome: A longitudinal MRI study

Shan

Kwiatek

Burnet

et al. 2016

Magnetic Resonance Imaging

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PurposeTo examine progressive brain changes associated with chronic fatigue syndrome (CFS).Materials and MethodsWe investigated progressive brain changes with longitudinal MRI in 15 CFS and 10 normal controls (NCs) scanned twice 6 years apart on the same 1.5 Tesla (T) scanner. MR images yielded gray matter (GM) volumes, white matter (WM) volumes, and T1‐ and T2‐weighted signal intensities (T1w and T2w). Each participant was characterized with Bell disability scores, and somatic and neurological symptom scores. We tested for differences in longitudinal changes between CFS and NC groups, inter group differences between pooled CFS and pooled NC populations, and correlations between MRI and symptom scores using voxel based morphometry. The analysis methodologies were first optimized using simulated atrophy.ResultsWe found a significant decrease in WM volumes in the left inferior fronto‐occipital fasciculus (IFOF) in CFS while in NCs it was unchanged (family wise error adjusted cluster level P value, P FWE < 0.05). This longitudinal finding was consolidated by the group comparisons which detected significantly decreased regional WM volumes in adjacent regions (P FWE < 0.05) and decreased GM and blood volumes in contralateral regions (P FWE < 0.05). Moreover, the regional GM and WM volumes and T2w in those areas showed significant correlations with CFS symptom scores (P FWE < 0.05).ConclusionThe results suggested that CFS is associated with IFOF WM deficits which continue to deteriorate at an abnormal rate. J. Magn. Reson. Imaging 2016;44:1301–1311.

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Section: Discussionmentioning

confidence: 99%

Progressive brain changes in patients with chronic fatigue syndrome: A longitudinal MRI study

Shan

Kwiatek

Burnet

et al. 2016

Magnetic Resonance Imaging

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“…In addition, like in vitro, this activity was completely unaltered in fine astrocytic processes upon IP3R2 deletion [35]. Interestingly, however, some studies (see [48] and [34]) suggest that, unlike in slices, cortical astrocytes mainly respond to sensory-evoked neuromodulator release (such as norepinephrine) rather than to neurotransmitter release (such as glutamate).…”

Section: (D) Calcium Activity In Astrocytesmentioning

confidence: 94%

“…D-serine, for example, was initially reported to be released following stimulation of mGluR by glutamate in cultured astrocytes [33]. However, evidence obtained in brain slices and in vivo suggests that the stimulation of cholinergic muscarinic receptors elicits D-serine release in the somatosensory cortex [34], while noradrenergic receptors could be involved in other regions of the cortex [35,36], and TRPA1 channels could be implicated in the hippocampus [37]. Most of these studies, however, have yet to be replicated, making it difficult to determine whether one of these pathways is the predominant route initiating D-serine release.…”

Section: (A) Morphological Interaction Of Astrocytic Processes With Smentioning

confidence: 99%

Astrocytic control of synaptic function

Papouin

Dunphy

Tolman

et al. 2017

Phil. Trans. R. Soc. B

180

136

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One contribution of 16 to a discussion meeting issue 'Integrating Hebbian and homeostatic plasticity'. Astrocytes intimately interact with synapses, both morphologically and, as evidenced in the past 20 years, at the functional level. Ultrathin astrocytic processes contact and sometimes enwrap the synaptic elements, sense synaptic transmission and shape or alter the synaptic signal by releasing signalling molecules. Yet, the consequences of such interactions in terms of information processing in the brain remain very elusive. This is largely due to two major constraints: (i) the exquisitely complex, dynamic and ultrathin nature of distal astrocytic processes that renders their investigation highly challenging and (ii) our lack of understanding of how information is encoded by local and global fluctuations of intracellular calcium concentrations in astrocytes. Here, we will review the existing anatomical and functional evidence of local interactions between astrocytes and synapses, and how it underlies a role for astrocytes in the computation of synaptic information.This article is part of the themed issue 'Integrating Hebbian and homeostatic plasticity'.

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“…ACh favours incoming thalamocortical sensory afferents relative to intracortical pathways [146,147], and combined BF and whisker stimulation increases whisker-evoked LFPs in the barrel cortex [148]. Interestingly, BF-ACh stimulation leads to activation of VIP-containing interneurons during locomotion in the visual cortex [149].…”

Section: (B) Basal Forebrain Cholinergic Pathway Stimulationevoked Nementioning

confidence: 99%

Neuronal networks and mediators of cortical neurovascular coupling responses in normal and altered brain states

Lecrux

Hamel

2016

Phil. Trans. R. Soc. B

103

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One contribution of 15 to a Theo Murphy meeting issue 'Interpreting BOLD: a dialogue between cognitive and cellular neuroscience'. Brain imaging techniques that use vascular signals to map changes in neuronal activity, such as blood oxygenation level-dependent functional magnetic resonance imaging, rely on the spatial and temporal coupling between changes in neurophysiology and haemodynamics, known as 'neurovascular coupling (NVC)'. Accordingly, NVC responses, mapped by changes in brain haemodynamics, have been validated for different stimuli under physiological conditions. In the cerebral cortex, the networks of excitatory pyramidal cells and inhibitory interneurons generating the changes in neural activity and the key mediators that signal to the vascular unit have been identified for some incoming afferent pathways. The neural circuits recruited by whisker glutamatergic-, basal forebrain cholinergic-or locus coeruleus noradrenergic pathway stimulation were found to be highly specific and discriminative, particularly when comparing the two modulatory systems to the sensory response. However, it is largely unknown whether or not NVC is still reliable when brain states are altered or in disease conditions. This lack of knowledge is surprising since brain imaging is broadly used in humans and, ultimately, in conditions that deviate from baseline brain function. Using the whisker-to-barrel pathway as a model of NVC, we can interrogate the reliability of NVC under enhanced cholinergic or noradrenergic modulation of cortical circuits that alters brain states.This article is part of the themed issue 'Interpreting BOLD: a dialogue between cognitive and cellular neuroscience'.

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Astrocyte Calcium Signaling Transforms Cholinergic Modulation to Cortical PlasticityIn Vivo

Cited by 344 publications

References 68 publications

Progressive brain changes in patients with chronic fatigue syndrome: A longitudinal MRI study

Progressive brain changes in patients with chronic fatigue syndrome: A longitudinal MRI study

Astrocytic control of synaptic function

Neuronal networks and mediators of cortical neurovascular coupling responses in normal and altered brain states

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