Astrochemistry: Ingredients of life in space

Petrignani, Annemieke; Candian, Alessandra

doi:10.1016/b978-0-12-824162-2.00007-5

Cited by 2 publications

(2 citation statements)

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“…Astrobiology also investigates the processes of prebiotic synthesis of organic molecules, and the evolution of the building blocks of life, or essentially, the primordial stage of life itself (Petrignani & Candian, 2022 ). To become a living thing, the chemical reactions need to connect and function as a network, known as a metabolic network, which regulates and determines the physiological processes of an organism.…”

Section: Metabolic Modelling In Astrobiology Contextmentioning

confidence: 99%

Genome‐scale metabolic modelling of extremophiles and its applications in astrobiological environments

Noirungsee,

Changkhong,

Phinyo

et al. 2024

Environ Microbiol Rep

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Metabolic modelling approaches have become the powerful tools in modern biology. These mathematical models are widely used to predict metabolic phenotypes of the organisms or communities of interest, and to identify metabolic targets in metabolic engineering. Apart from a broad range of industrial applications, the possibility of using metabolic modelling in the contexts of astrobiology are poorly explored. In this mini‐review, we consolidated the concepts and related applications of applying metabolic modelling in studying organisms in space‐related environments, specifically the extremophilic microbes. We recapitulated the current state of the art in metabolic modelling approaches and their advantages in the astrobiological context. Our review encompassed the applications of metabolic modelling in the theoretical investigation of the origin of life within prebiotic environments, as well as the compilation of existing uses of genome‐scale metabolic models of extremophiles. Furthermore, we emphasize the current challenges associated with applying this technique in extreme environments, and conclude this review by discussing the potential implementation of metabolic models to explore theoretically optimal metabolic networks under various space conditions. Through this mini‐review, our aim is to highlight the potential of metabolic modelling in advancing the study of astrobiology.

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Section: Metabolic Modelling In Astrobiology Contextmentioning

confidence: 99%

Genome‐scale metabolic modelling of extremophiles and its applications in astrobiological environments

Noirungsee,

Changkhong,

Phinyo

et al. 2024

Environ Microbiol Rep

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“…Interstellar complex organic molecules (iCOMs) encompass various chemical entities, including alcohols, amines, carboxylic acids, aldehydes, and ketones. These iCOMs typically consist of six or more atoms, , and certain iCOMs, including nucleobases, amino acids, and sugar derivatives, hold particular astrobiological interest . These organic compounds have been identified in meteorites such as the carbonaceous chondrites of Murchison (1969), Rennazo (1824), Murray (1950), and Ivuna (1938), , suggesting that the essential building blocks of life might have arrived on early Earth via meteoritic impacts. − …”

Section: Introductionmentioning

confidence: 99%

In Quest of the Missing C₂H₆O₂ Isomers in the Interstellar Medium: A Theoretical Search

Noriega,

Gonzalez-Ortiz,

Ortíz-Chi

et al. 2024

J. Phys. Chem. A

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Ethylene glycol (C 2 H 6 O 2 ), the only diol detected in the interstellar medium (ISM), is a key component in the synthesis of prebiotic sugars. Its structural isomer, methoxymethanol, has also been found in the ISM. Our results show that neither ethylene glycol (ethane-1,2-diol) nor methoxymethanol is the most stable isomer. Using high-level computational methods, we identified five isomers: two diols, one hydroxy ether, and two peroxides. The geminal diol 1,1-ethanediol (ethane-1,1-diol) is the most stable isomer, although it has not been detected in the ISM, whereas the two peroxides are less stable than the geminal diol by 60 kcal/mol. This study also provides the rotational constants and dipole moment for each conformer of every C 2 H 6 O 2 isomer.

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Astrochemistry: Ingredients of life in space

Cited by 2 publications

References 100 publications

Genome‐scale metabolic modelling of extremophiles and its applications in astrobiological environments

Genome‐scale metabolic modelling of extremophiles and its applications in astrobiological environments

In Quest of the Missing C₂H₆O₂ Isomers in the Interstellar Medium: A Theoretical Search

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Astrochemistry: Ingredients of life in space

Cited by 2 publications

References 100 publications

Genome‐scale metabolic modelling of extremophiles and its applications in astrobiological environments

Genome‐scale metabolic modelling of extremophiles and its applications in astrobiological environments

In Quest of the Missing C2H6O2 Isomers in the Interstellar Medium: A Theoretical Search

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In Quest of the Missing C₂H₆O₂ Isomers in the Interstellar Medium: A Theoretical Search