Inside-Out Planet Formation (IOPF) proposes that the abundant systems of close-in Super-Earths and Mini-Neptunes form in situ at the pressure maximum associated with the Dead Zone Inner Boundary (DZIB). We present a model of physical and chemical evolution of protoplanetary disk midplanes that follows gas advection, radial drift of pebbles and gas-grain chemistry to predict abundances from ∼ 300 au down to the DZIB near 0.2 au. We consider typical disk properties relevant for IOPF, i.e., accretion rates 10 −9 < 𝑚/(𝑀 yr −1 ) < 10 −8 and viscosity parameter 𝛼 = 10 −4 , and evolve for fiducial duration of 10 5 yrs. For outer, cool disk regions, we find that C and up to 90% of O nuclei start locked in CO and O 2 ice, which keeps abundances of CO 2 and H 2 O one order of magnitude lower. Radial drift of icy pebbles is influential, with gas-phase abundances of volatiles enhanced up to two orders of magnitude at ice-lines, while the outer disk becomes depleted of dust. Disks with decreasing accretion rates gradually cool, which draws in icelines closer to the star. At 1 au, advective models yield water-rich gas with C/O ratios 0.1, which may be inherited by atmospheres of planets forming here via IOPF. For planetary interiors built by pebble accretion, IOPF predicts volatile-poor compositions. However, advectively-enhanced volatile mass fractions of ∼ 10% can occur at the water ice line.