“…Based on their observations, they conclude that phosphatase activity could act as an activity biomarker in extreme environments on the Earth and beyond. Brack (2022), (this issue) provides his own summary of the most important factors in the emergence of life: liquid water and the necessity of some form of wet-dry cycling; organic molecules of terrestrial or extraterrestrial origin; inorganic substrates, such as clays or silica gel providing attributes, such as protection, catalysation, serving as templates, absorption etc. ; a suitable environment, such as hydrothermal systems (subaqueous or subaerial); far from equilibrium wet-dry cycling reactants based on mineral surfaces in hydrothermal systems; an approach based on systems chemistry, which allows all the cellular subsystems to simultaneously emerge.…”