Astragalus polysaccharides combined with Codonopsis pilosula polysaccharides modulates the physiological characteristics of trophoblasts via miR-92a-1–5p/CCR7 axis

Chen, Yi; Yu, Cheng; Hu, Fengli; Zhu, Yongfa; Xie, Xianjun

doi:10.1016/j.tice.2022.101827

Tissue and Cell

2022

DOI: 10.1016/j.tice.2022.101827

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Astragalus polysaccharides combined with Codonopsis pilosula polysaccharides modulates the physiological characteristics of trophoblasts via miR-92a-1–5p/CCR7 axis

Yi Chen

Cheng Yu

Fengli Hu

et al.

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2024

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Cited by 3 publications

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“…It can enhance immune function and promote the development and proliferation of stem cells. It has been proved that it can promote the growth, proliferation and differentiation of many kinds of stem cells [6] . In light of this, this study investigated the impact of APS on angiogenesis of human ADSCs, in order to provide reference for the choice of clinical treatment.…”

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confidence: 99%

Investigating the Impact of Astragalus Polysaccharide on Angiogenesis in Human Adipose-Derived Stem Cells

Ke,

Jun,

Jingjun

et al. 2024

IJPS

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This study aims to investigate the influence ofAstragalus polysaccharides on angiogenesis in human adiposederived stem cells. Three experimental groups were established; control group (group A), a low-dose Astragalus polysaccharides intervention group (group B), and a high-dose Astragalus polysaccharides intervention group (group C). Group A comprised untreated human adipose-derived stem cells cultured under standard conditions. Group B received an Astragalus polysaccharides concentration of 80 µg/ml, while group C was treated with 160 µg/ml of Astragalus polysaccharides. Cell proliferation, migration, and angiogenic potential were assessed using cell counting kit-8 assay, Western blot analysis, quantitative polymerase chain reaction, and Transwell migration assays. Relative to group A, group B exhibited enhanced cell migration and proliferation, with further increases observed in group C. Angiopoietin-1 and vascular endothelial growth factor levels were elevated in group B compared to group A, with an additional increase in group C. Conversely, the expression levels of pro-apoptotic proteins Bcl-2-associated X protein and caspase-3 were decreased in group B relative to group A, and further reduced in group C. Hypoxia-inducible factor 1 and nuclear factor kappa B expression were diminished in group B compared to group A, with a more pronounced reduction in group C. Astragalus polysaccharides modulate angiogenesis in human adipose-derived stem cells by downregulating nuclear factor kappa B expression, thereby inhibiting hypoxia-inducible factor 1 and nuclear factor kappa B pathways. This modulation facilitates the proliferation and angiogenic activity of adipose-derived stem cells, suggesting a promising therapeutic potential of Astragalus polysaccharides in regenerative medicine and tissue engineering.

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confidence: 99%

Investigating the Impact of Astragalus Polysaccharide on Angiogenesis in Human Adipose-Derived Stem Cells

Ke,

Jun,

Jingjun

et al. 2024

IJPS

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MiR-221 on protective oxidative induced by selenium modified Codonopsis pilosula polysaccharide

Qin,

Sun,

Huang

et al. 2024

International Journal of Biological Macromolecules

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On the miRNAs-regulated mechanisms by which natural plant polysaccharides control apoptosis

Wang,

Duan,

et al. 2024

Pharmacological Research - Modern Chinese Medicine

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Astragalus polysaccharides combined with Codonopsis pilosula polysaccharides modulates the physiological characteristics of trophoblasts via miR-92a-1–5p/CCR7 axis

Cited by 3 publications

References 57 publications

Investigating the Impact of Astragalus Polysaccharide on Angiogenesis in Human Adipose-Derived Stem Cells

Investigating the Impact of Astragalus Polysaccharide on Angiogenesis in Human Adipose-Derived Stem Cells

MiR-221 on protective oxidative induced by selenium modified Codonopsis pilosula polysaccharide

On the miRNAs-regulated mechanisms by which natural plant polysaccharides control apoptosis

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