Astragalus polysaccharide upregulates hepcidin and reduces iron overload in mice via activation of p38 mitogen-activated protein kinase

Ren, Feng; Qian, Xinhua; Qian, Xiaohong

doi:10.1016/j.bbrc.2016.02.088

Cited by 25 publications

(15 citation statements)

References 29 publications

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“…In pathological conditions, APS can downregulate the activity of mTOR and protect cells. In a study investigating the effect of APS on iron-overloaded mice, APS activated the p38/mitogen-activated protein kinase (p38/ MAPK) signal transduction pathway in vitro (Ren et al, 2016).…”

Section: Downregulationmentioning

confidence: 99%

A Review of the Pharmacological Action of Astragalus Polysaccharide

et al. 2020

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Astragalus membranaceus (A. membranaceus) is a type of traditional Chinese medicine with a long history of clinical application. It is used in the improvement and treatment of various diseases as medicine and food to invigorate the spleen and replenish qi. The main components of A. membranaceus are Astragalus polysaccharide (APS), flavonoids compounds, saponins compounds, alkaloids, etc. APS is the most important natural active component in A. membranaceus, and possesses multiple pharmacological properties. At present, APS possess the huge potential to develop a drug improving or treating different diseases. In this review, we reveal the potential approaches of pretreating and preparation on APS as much as possible and the study on content of APS and its chemical composition including different monosaccharides. More importantly, this paper summarize pharmacological actions on immune regulation, such as enhancing the immune organ index, promoting the proliferation of immune cells, stimulating the release of cytokines, and affecting the secretion of immunoglobulin and conduction of immune signals; anti-aging; anti-tumor by enhancing immunity, inducing apoptosis of tumor cells and inhibiting the proliferation and transfer of tumor cells; antiviral effects; regulation of blood glucose such as type I diabetes mellitus, type II diabetes mellitus and diabetic complications; lipid-lowering; anti-fibrosis; antimicrobial activities and anti-radiation. It provided theoretical basis for the further research such as its structure and mechanism of action, and clinical application of APS.

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Section: Downregulationmentioning

confidence: 99%

A Review of the Pharmacological Action of Astragalus Polysaccharide

et al. 2020

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“…These traditional Chinese herbs have been used for thousands of years for their anti-cancer and immunomodulatory properties. Recently, astragalus-derived polysaccharides were reported to suppress the accumulation of ROS and Nrf1 in human cardiac myocytes [ 85 ] and to increase hepcidin expression by activating the p38 mitogen-activated protein kinase (MAPK) signaling pathway and the release of IL-6 [ 86 ]. Angelica sinensis can protect chondrocytes from H 2 O 2 -induced oxidative stress by inducing changes in cell viability, SOD activity, catalase activity, malondialdehyde production, apoptosis, and inflammatory cytokines [ 87 ].…”

Section: Bioactive Compounds That Regulate Oxidative Stress and Irmentioning

confidence: 99%

Antioxidants Mediate Both Iron Homeostasis and Oxidative Stress

et al. 2017

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Oxidative stress is a common denominator in the pathogenesis of many chronic diseases. Therefore, antioxidants are often used to protect cells and tissues and reverse oxidative damage. It is well known that iron metabolism underlies the dynamic interplay between oxidative stress and antioxidants in many pathophysiological processes. Both iron deficiency and iron overload can affect redox state, and these conditions can be restored to physiological conditions using iron supplementation and iron chelation, respectively. Similarly, the addition of antioxidants to these treatment regimens has been suggested as a viable therapeutic approach for attenuating tissue damage induced by oxidative stress. Notably, many bioactive plant-derived compounds have been shown to regulate both iron metabolism and redox state, possibly through interactive mechanisms. This review summarizes our current understanding of these mechanisms and discusses compelling preclinical evidence that bioactive plant-derived compounds can be both safe and effective for managing both iron deficiency and iron overload conditions.

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“…Numerous recent studies have focused their attention on the possibility of pharmacologically modulating HEPC expression [65], with the intent to reduce anemia in chronic diseases. Among these molecules, some natural compounds could be used as nutraceuticals [73][74][75][76][77][78].…”

Section: Figurementioning

confidence: 99%

Iron Absorption in Celiac Disease and Nutraceutical Effect of 7-Hydroxymatairesinol. Mini-Review

et al. 2020

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Anemia is the main extra-gastrointestinal symptom in inflammatory bowel diseases (IBDs). Interleukin-6 (IL-6) and other cytokines are secreted and act in the microenvironment of the small intestine mucous membrane of IBD patients. Iron is essential for multiple cell functions and its homeostasis is regulated by the hepcidin–ferroportin axis. Hepcidin (HEPC) is mainly produced by the liver in response to iron needs but is also an acute phase protein. During inflammation, hepcidin is upregulated by IL-6 and is responsible for iron compartmentalization within cells, in turn causing anemia of inflammation. Tissues other than liver can produce hepcidin in response to inflammatory stimuli, in order to decrease iron efflux at a local level, then acting in an autocrine–paracrine manner. In IBDs and, in particular, in celiac disease (CeD), IL-6 might trigger the expression, upregulation and secretion of hepcidin in the small intestine, reducing iron efflux and exacerbating defective iron absorption. 7-Hydroxymatairesinol (7-HMR) belongs to the family of lignans, polyphenolic compounds produced by plants, and has nutraceutical antioxidant, anti-inflammatory and estrogenic properties. In this mini-review we revise the role of inflammation in IBDs and in particular in CeD, focusing our attention on the close link among inflammation, anemia and iron metabolism. We also briefly describe the anti-inflammatory and estrogenic activity of 7-HMR contained in foods that are often consumed by CeD patients. Finally, considering that HEPC expression is regulated by iron needs, inflammation and estrogens, we explored the hypothesis that 7-HMR consumption could ameliorate anemia in CeD using Caco-2 cells as bowel model. Further studies are needed to verify the regulation pathway through which 7-HMR may interfere with the local production of HEPC in bowel.

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Astragalus polysaccharide upregulates hepcidin and reduces iron overload in mice via activation of p38 mitogen-activated protein kinase

Cited by 25 publications

References 29 publications

A Review of the Pharmacological Action of Astragalus Polysaccharide

A Review of the Pharmacological Action of Astragalus Polysaccharide

Antioxidants Mediate Both Iron Homeostasis and Oxidative Stress

Iron Absorption in Celiac Disease and Nutraceutical Effect of 7-Hydroxymatairesinol. Mini-Review

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