Astragalus polysaccharide exerts anti-Parkinson via activating the PI3K/AKT/mTOR pathway to increase cellular autophagy level in vitro

Tan, Yinyin; Yin, Ling; Sun, Zhanfang; Shao, Shanshan; Chen, Wenbin; Xiao, Mochao; Du, Yifeng; Chen, Yan

doi:10.1016/j.ijbiomac.2020.02.282

Cited by 39 publications

(21 citation statements)

References 24 publications

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“…(family Apiaceae, genus Centella ), has been shown to effectively provide neuroprotection for MPTP-induced neuron cell loss through ERK and PI3K/AKT/mTOR/GSK-3 pathway ( Nataraj et al, 2017 ). The phosphorylation levels of AKT and mTOR could be increased by both Lycium barbarum polysaccharide (LBP) ( Wang et al, 2018b ) and Astragalus polysaccharides (APS) ( Tan et al, 2020 ), effectively alleviate the nigral striatal system degeneration and regulation of cell autophagy, thereby affecting the occurrence and development of PD.…”

Section: Natural Products For Prevention and Treatment Of Parkinson’s Disease Based On Pi3k/akt Pathawymentioning

confidence: 99%

PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer’s Disease and Parkinson’s Disease

et al. 2021

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Alzheimer’s disease (AD) and Parkinson’s disease (PD) are two typical neurodegenerative diseases that increased with aging. With the emergence of aging population, the health problem and economic burden caused by the two diseases also increase. Phosphatidylinositol 3-kinases/protein kinase B (PI3K/AKT) signaling pathway regulates signal transduction and biological processes such as cell proliferation, apoptosis and metabolism. According to reports, it regulates neurotoxicity and mediates the survival of neurons through different substrates such as forkhead box protein Os (FoxOs), glycogen synthase kinase-3β (GSK-3β), and caspase-9. Accumulating evidences indicate that some natural products can play a neuroprotective role by activating PI3K/AKT pathway, providing an effective resource for the discovery of potential therapeutic drugs. This article reviews the relationship between AKT signaling pathway and AD and PD, and discusses the potential natural products based on the PI3K/AKT signaling pathway to treat two diseases in recent years, hoping to provide guidance and reference for this field. Further development of Chinese herbal medicine is needed to treat these two diseases.

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Section: Natural Products For Prevention and Treatment Of Parkinson’s Disease Based On Pi3k/akt Pathawymentioning

confidence: 99%

PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer’s Disease and Parkinson’s Disease

et al. 2021

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“…Dong et al showed that AP could reduce the gene expression of inflammatory factors and chemokines by inhibiting the phosphorylation of NF-κB in lipopolysaccharide-stimulated porcine intestinal epithelial cells, and the alleviation of inflammatory response was verified in BALB/c mice after AP administration [14]. Studies have shown that AS and AP possess other biological activities, such as anti-tumor, anti-apoptosis, neuroprotection, and anti-Parkinson properties, as well as the improvement of insulin resistance [11,[15][16][17], whereas the role of AS and AP in attenuating ALD remains poorly understood. In view of these bioactive properties above, we wondered whether AS and AP were potentially of benefit for the management of ALD.…”

Section: Introductionmentioning

confidence: 99%

Astragalus Polysaccharides and Saponins Alleviate Liver Injury and Regulate Gut Microbiota in Alcohol Liver Disease Mice

Zhou

Zhang

Zhao

et al. 2021

Foods

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Astragalus, a medical and edible plant in China, shows several bioactive properties. However, the role of astragalus in attenuating alcoholic liver disease (ALD) is less clear. The objective of this project is to investigate the improving effect of astragalus saponins (AS) and astragalus polysaccharides (AP), which are the two primary constituents in astragalus on hepatic injury induced by alcohol, and the potential mechanisms of action. Different doses of AS (50 and 100 mg/kg bw) and AP (300 and 600 mg/kg bw) were orally given to alcohol-treated mice for four weeks. The results demonstrated that both AP and AS could reverse the increase of the levels of TC, TG, FFA, and LDL-C in serum, and the decrease of serum HDL-C content, as well as the elevation of hepatic TC and TG levels induced by alcohol. The activities of AST, ALT, ALP, and γ-GT in ALD mice were raised after AP and AS supplementation. The antioxidant markers (SOD, CAT, GSH, and GSH-Px) were obviously augmented and the pro-inflammatory cytokines (TNF-α, IL-6 and IL-1β) and hepatic histological variations were alleviated by AP and AS, which was in line with the levels of oxidative stress-associated genes (Keap1, Nfe2l2, Nqo1, and Hmox1) and inflammation-associated genes (Tlr4, Myd88 and Nfkb1). In addition, AS exerted a more efficient effect than AP and the results presented dose proportionality. Moreover, AS and AP could modulate the intestinal microbiota disturbance induced by alcohol. Overall, AS and AP administration could ameliorate lipid accumulation in the serum and liver, as well as hepatic function, oxidative stress, inflammatory response, and gut flora disorders in mice as a result of alcohol.

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“…We can nd that treatment effects of WYHY decoction is better than XQL decoction in the regulation of autophagy and improved airway in ammation. The reason may be that WYHY added Ginseng (Radix et Rhizoma) and Astragali (Radix) on the basis of XQL decoction.Many experimental studies have found that Ginseng and Astragali can regulating the autophagy related gene through PI3K-mTOR pathway [44][45][46][47][48][49], and Ginseng and Astragali can also alleviate various kinds of in ammation [50][51][52][53][54]. Therefore, according to the results of this experiment, it can be concluded that WYHY decoction can better regulate autophagy and alleviate airway in ammation of cold asthma rats by added Ginseng (Radix et Rhizoma) and Astragali (Radix).…”

Section: Discussionmentioning

confidence: 81%

Winyanghuayin Decoction and Xiaoqinglong Decoction Treatment Airway Inflammation of Cold Asthma Through PI3K-mTOR Signal Pathway

Chang

Zhang

Qing-xiang

et al. 2020

Preprint

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Abstract Background: Airway inflammation plays a pivotal role in cold asthma. Winyanghuayin decoction and Xiaoqinglong decoction can significantly improve airway inflammation. The aim of the present study was to explore the therapeutic effect and mechanism of Winyanghuayin decoction and Xiaoqinglong decoction on OVA-induced cold asthma in rat and compare the effects of Winyanghuayin decoction and Xiaoqinglong decoction for treatment of cold asthma ratsMethods: The cold asthma rat model was induced by OVA and ice water swim stress, treated with Winyanghuayin decoction and Xiaoqinglong decoction respectively. The pulmonary function of asthmatic rats was detected by MIR Spirolab; The pathological changes of lung tissue were observed by HE staining; The autophagy in the lung of rats were observed by transmission electron microscopy; The eosinophils, lymphocytes, macrophages and total cells in bronchoalveolar lavage fluid (BALF) were counted under light microscope. The expression of IL-10\IL-13\TNF-α and TGF-β1 in serum were measured by enzyme-linked immunosorbent assay (ELISA); The protein level of LC3-II\I, ATG, PI3K and mTOR expression in lung tissues were detected by Western blot; Real-time polymerase chain reaction (RT-PCR) detected the expression of autophagy gene ATG3\ATG5\ATG7 and ATG12.Results: Winyanghuayin decoction and Xiaoqinglong decoction can alleviate airway inflammation and improve airway hyper-responsiveness, significantly increased the level of autophagy in lung tissue and decreased the protein level of PI3K and mTOR in lung tissue of cold asthma rats. Winyanghuayin decoction have better regulation ability on autophagy and PI3K-mTOR signaling pathway.Conclusion: Winyanghuayin decoction and Xiaoqinglong decoction may alleviate the airway inflammation symptoms by enhancing autophagy in lung tissue dependent on the PI3K-mTOR signaling pathway. Winyanghuayin decoction was more effective than Xiaoqinglong decoction for treatment of cold asthma.

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Astragalus polysaccharide exerts anti-Parkinson via activating the PI3K/AKT/mTOR pathway to increase cellular autophagy level in vitro

Cited by 39 publications

References 24 publications

PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer’s Disease and Parkinson’s Disease

PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer’s Disease and Parkinson’s Disease

Astragalus Polysaccharides and Saponins Alleviate Liver Injury and Regulate Gut Microbiota in Alcohol Liver Disease Mice

Winyanghuayin Decoction and Xiaoqinglong Decoction Treatment Airway Inflammation of Cold Asthma Through PI3K-mTOR Signal Pathway

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