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Background:: Astragalus, as a common traditional Chinese medicine (TCM), has many pharmacological effects, such as protection of nerves, heart, blood vessels, kidneys, etc. It can also be used to treat colds, numbness, diarrhea, indigestion, and anemia. Because of the current market, there are a large number of synonyms, synonyms, and multiple sources of one medicine. The use of near-edge plants in medicine and other fake, substandard as a good phenomenon also prevails. Methods:: In this study, a method combining electrochemical fingerprinting with SPSS software was developed to identify the origin of Astragalus membranaceus. The electrochemical fingerprints of Astragalus membranaceus with different accessions and different origins were examined using an electrochemical workstation. Then the characteristic parameters were selected to achieve the origin identification of Astragalus with SPSS software using cluster analysis and discriminant analysis. Results:: The results of this method divided the origin of Astragalus into the Qinling production area and other production areas. Conclusion:: This method can be used to identify the origin of Astragalus membranaceus, which provides a new method to identify Astragalus membranaceus and other TCM without extracting the active ingredients of Chinese medicines, in line with the traditional "holistic" treatment concept of TCM.
Background:: Astragalus, as a common traditional Chinese medicine (TCM), has many pharmacological effects, such as protection of nerves, heart, blood vessels, kidneys, etc. It can also be used to treat colds, numbness, diarrhea, indigestion, and anemia. Because of the current market, there are a large number of synonyms, synonyms, and multiple sources of one medicine. The use of near-edge plants in medicine and other fake, substandard as a good phenomenon also prevails. Methods:: In this study, a method combining electrochemical fingerprinting with SPSS software was developed to identify the origin of Astragalus membranaceus. The electrochemical fingerprints of Astragalus membranaceus with different accessions and different origins were examined using an electrochemical workstation. Then the characteristic parameters were selected to achieve the origin identification of Astragalus with SPSS software using cluster analysis and discriminant analysis. Results:: The results of this method divided the origin of Astragalus into the Qinling production area and other production areas. Conclusion:: This method can be used to identify the origin of Astragalus membranaceus, which provides a new method to identify Astragalus membranaceus and other TCM without extracting the active ingredients of Chinese medicines, in line with the traditional "holistic" treatment concept of TCM.
Introduction. Human performance depends on external and internal factors. Of a number of external factors, the environmental aspect is one of the leading ones. Internal factors are interrelated with external ones. The latter include the general condition of the human body, as well as the normal functioning of individual systems and organs. It must be noted that the use of herbal drugs in order to prevent the development of pathologies caused by internal factors is rational. A number of plants contain substances that can improve performance by strengthening the cardiovascular system, normalizing the liver, adjusting daily rhythms, reducing stress. In this regard, the development of the composition and technology of drugs based on substances of plant origin does not lose relevance.Aim. Development of the composition of solid oral dosage form based on dry extract of Astragalus membranaceus (Fisch.) Bunge containing saponins.Materials and methods. As an object of research, a substance was used – dry extract of Astragalus membranaceus (Fisch.) Bunge, standardized in accordance with the requirements of SP XIV ed. Lactose monohydrate, calcium stearate, methylcellulose, corn starch, talc were used as excipients in the tablet technology. Under laboratory conditions, granulation was carried out by the wet mass extrusion method. A 3 % methylcellulose solution was used as the wetting reagent. Quality parameters of the final dosage form, tablets, were determined according to the methods described in SP XIV ed.Results and discussion. As a result of the conducted research, the composition of a solid oral dosage form based on a dry extract of Astragalus membranaceus (Fisch.) Bunge was proposed. The main quality indicators of the obtained dosage form are determined. A design quality specification has been developed for a drug.Conclusion. The present study proposed technology dry extract for Astragalus membranaceus (Fisch.) Bunge herb. Quality index of the obtained plant substance are determined. The composition and technology of tablets based on the dry extract of Astragalus membranaceus (Fisch.) Bunge herb have been developed. The main quality indicators of tablets based on the dry extract of Astragalus membranaceus (Fisch.) Bunge herb were determined. A draft quality specification of the resulting dosage form has been developed.
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