Astragalus Injection for Hypertensive Renal Damage: A Systematic Review

Sun, Tao; Xu, Hao; Xu, Fengqin

doi:10.1155/2012/929025

Cited by 9 publications

(10 citation statements)

References 2 publications

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“…Thirdly, the primary goal of treatment for EH is to reduce the mortality or prevent progression to severe complications [64]. Only one trial [26] reported the 5-year follow-up of Tai Chi.…”

Section: Discussionmentioning

confidence: 99%

Tai Chi for Essential Hypertension

Wang

Feng

Yang

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Objectives. To assess the current clinical evidence of Tai Chi for essential hypertension (EH). Search Strategy. 7 electronic databases were searched until 20 April, 2013. Inclusion Criteria. We included randomized trials testing Tai Chi versus routine care or antihypertensive drugs. Trials testing Tai Chi combined with antihypertensive drugs versus antihypertensive drugs were also included. Data Extraction and Analyses. Study selection, data extraction, quality assessment, and data analyses were conducted according to the Cochrane standards. Results. 18 trials were included. Methodological quality of the trials was low. 14 trials compared Tai Chi with routine care. 1 trial compared Tai Chi with antihypertensive drugs. Meta-analysis all showed significant effect of TaiChi in lowering blood pressure (BP). 3 trials compared Tai Chi plus antihypertensive drugs with antihypertensive drugs. Positive results in BP were found in the other 2 combination groups. Most of the trials did not report adverse events, and the safety of Tai Chi is still uncertain. Conclusions. There is some encouraging evidence of Tai Chi for EH. However, due to poor methodological quality of included studies, the evidence remains weak. Rigorously designed trials are needed to confirm the evidence.

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“…Thirdly, the primary goal of treatment for EH is to reduce the mortality or prevent progression to severe complications [64]. Only one trial [26] reported the 5-year follow-up of Tai Chi.…”

Section: Discussionmentioning

confidence: 99%

Tai Chi for Essential Hypertension

Wang

Feng

Yang

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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“…An important reason is that achievements in herbal pharmacology cannot be effectively converted to appropriate clinical use. It is thought that syndrome differentiation, the traditional therapy, has perfect effects in improving the signs, symptoms, and syndrome in TCM, but poor effects in treating disease (and even no effects in improving the key indicators of diseases) [84]. Therefore, application of the achievements of herbal pharmacology in clinical treatment is an important reference for lowering BP using Chinese herbs and formulas.…”

Section: Application Of Herbal Pharmacological Achievements In CLImentioning

confidence: 99%

Trends in the Treatment of Hypertension from the Perspective of Traditional Chinese Medicine

Xiong

Yang

Liu

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Hypertension is a major public-health issue. Much consensus has been reached in the treatment, and considerable progress has been made in the field of antihypertensive drugs. However, the standard-reaching rate of blood pressure is far from satisfaction. Considering these data and the seriousness of the effects of hypertension on the individual and society as a whole, both economically and socially, physicians must look for more effective and alternative ways to achieve the target blood pressure. Could treatment of hypertension be improved by insights from traditional Chinese medicine? As one of the most important parts in complementary and alternative therapies, TCM is regularly advocated for lowering elevated blood pressure. Due to the different understanding of the pathogenesis of hypertension between ancient and modern times, new understanding and treatment of hypertension need to be reexplored. Aiming to improve the efficacy of Chinese herbal medicine in treating hypertension, the basis of treatment is explored through systematically analyzing the literature available in both English and Chinese search engines. This paper systematically reviews the trends in emerging therapeutic strategies for hypertension from the perspective of traditional Chinese medicine.

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“…Multicenter randomized controlled clinical trials have shown that CHM therapy improves estimated glomerular filtration rate (eGFR) in both patients with stage 3chronic kidney disease (CKD) and idiopathic membranous nephropathy [ 13 , 14 ]. Many CHM preparations have been used in treating CKD in China, and systematic reviews have shown that some are effective [ 15 , 16 ]. Investigations on CHM treatment of DKD have been undertaken in China.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of Tangshen Formula on Patients with Type 2 Diabetic Kidney Disease: A Multicenter Double-Blinded Randomized Placebo-Controlled Trial

et al. 2015

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BackgroundPersons with diabetes are at high risk of developing diabetic kidney disease (DKD), which is associated with high morbidity and mortality. Current drug therapies for DKD, such as angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs), are not entirely satisfactory. This study aimed to evaluate the additional benefit and safety of the Chinese herbal granule Tangshen Formula (TSF) in treating DKD.MethodsThe study was designed as a six-center randomized, double-blind, placebo-controlled trial. From April 2007 through December 2009, 180 patients with DKD were enrolled. In addition to conventional treatment with ACEIs or ARBs, 122 participants were randomly assigned to receive TSF and 58 participants to receive placebo for 24 weeks. Primary outcome was urinary protein level, measured by urinary albumin excretion rate (UAER) for participants with microalbuminuria, 24-hour urinary protein (24h UP) for participants with macroalbuminuria. Secondary outcomes included renal function, serum lipids, quality of life, symptoms, and adverse events.FindingsAfter 24 weeks of treatment, no statistically significant difference in UAER (TSF −19.53 μg/min compared with placebo −7.01 μg/min, with a mean difference of −12.52 μg/min; 95%CI, −68.67 to 43.63, P = 0.696) was found between TSF and placebo groups. However, TSF displayed a statistically significant decrease in 24h UP (TSF−0.21 g compared with placebo 0.36 g, with a mean difference of −0.57g; 95%CI, −1.05 to −0.09, P = 0.024). Estimated glomerular filtration rate (eGFR) was improved in both patients with microalbuminuria and macroalbuminuria, with a mean difference of 15.51 ml/min/1.73 m2 (95%CI, 3.71 to 27.31), 9.01 ml/min/1.73 m2 (95%CI, −0.10 to 18.13), respectively. Other secondary outcomes showed no statistically significant difference between groups or in the incidence of adverse events.ConclusionsBased on conventional treatments, TSF appears to provide additional benefits compared with placebo in decreasing proteinuria and improving eGFR in DKD patients with macroalbuminuria. Nevertheless, further study is needed to evaluate TSF treating patients with microalbuminuria.Trial RegistrationChinese Clinical Trial Registry ChiCTR-TRC-10000843

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Astragalus Injection for Hypertensive Renal Damage: A Systematic Review

Cited by 9 publications

References 2 publications

Tai Chi for Essential Hypertension

Tai Chi for Essential Hypertension

Trends in the Treatment of Hypertension from the Perspective of Traditional Chinese Medicine

Efficacy and Safety of Tangshen Formula on Patients with Type 2 Diabetic Kidney Disease: A Multicenter Double-Blinded Randomized Placebo-Controlled Trial

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