Astragaloside IV protects against focal cerebral ischemia/reperfusion injury correlating to suppression of neutrophils adhesion-related molecules

Astragaloside IV Ameliorates Renal Fibrosis via the Inhibition of Mitogen-Activated Protein Kinases and Antiapoptosis In Vivo and In Vitro

“…These results suggest that increasing the activation of the JNK and p38 MAPK pathways might play a prominent role in renal tubular cell apoptosis (thus, subsequently accelerating the progression of renal tubulointerstitial fibrosis), and the inhibitory effect of AS-IV on cell apoptosis may be related to the inhibition of these two MAPK signaling pathways. Similar studies have been performed on the protective effect of AS-IV in renal injury and pathology (Meng et al, 2011;Zhang et al, 2011;Li et al, 2012;Qin et al, 2012;Gui et al, 2013;Qi et al, 2014). Meng et al (2011) performed a study in UUO rats using AS-IV and ferulic acid as treatments.…”

Neuroprotective effects of lycopene pretreatment on transient global cerebral ischemia-reperfusion in rats: The role of the Nrf2/HO-1 signaling pathway

“…Ischemic stroke is currently a leading cause of cerebrovascular disease worldwide, and exhibits a high morbidity and mortality among patients (1). Ischemic stroke is induced by a transient or permanent occlusion in the cerebral vessel, resulting in neuronal death and associated behavioral deficits, including sensorimotor dysfunction, spatial orientation disorder, and learning and memory impairment (2)(3)(4).…”

Astragaloside IV reduces cerebral edema post-ischemia/reperfusion correlating the suppression of MMP-9 and AQP4

“…1), is one of the major and active components of the astragalus membranaceus, which has showed significant efficacy against oxidative stress injury and inflammation in mice and rats models (Luo et al, 2004;Li et al, 2012;Yin et al, 2010). Moreover, astragaloside IV has a property of inhibiting degradation of occluding and Zonula occluden-1 (Zo-1) in rat I/R model (Qu et al, 2009).…”