Asthme et tuberculose : association bénéfique ou maléfique ?

Fekih, L.; Boussoffara, L.; Jemaa, M. Ben; Fenniche, Samy; Hassene, H.; Belhabib, D.; Megdiche, M.L.

doi:10.1016/j.rmr.2010.06.010

Cited by 4 publications

(1 citation statement)

References 25 publications

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“…It damages the lungs and reduces anti-TB treatment efficacy. 39 In the current study, age was not associated with RR-MTB. However, previous studies associated age with RR-MTB.…”

Section: Discussioncontrasting

confidence: 41%

Rifampicin resistant Mycobacterium tuberculosis and associated factors among presumptive pulmonary tuberculosis patients in Mogadishu, Somalia

et al. 2023

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Background: Multi-drug resistant Mycobacterium tuberculosis is a growing public health problem in developing countries including Somalia. Although, the prevalence of multi-drug resistant tuberculosis among new and retreated cases is high, data on GeneXpert- Mycobacterium tuberculosis/rifampicin-resistant assay, which is a surrogate marker for multidrug resistance, is not well explored in Mogadishu. Objectives: To determine the prevalence of rifampicin-resistant Mycobacterium tuberculosis and its associated factors among presumptive pulmonary tuberculosis patients visiting tuberculosis centers in Mogadishu, Somalia. Methods: A multicenter cross-sectional study was conducted in three tuberculosis treatment centers from March 12 to April 30, 2021. Laboratory professionals collected sputum sample consecutively from presumptive pulmonary tuberculosis participants and performed a GeneXpert assay to determine the rifampicin resistance. Socio-demographic and clinical data were collected using structured questionnaire. Logistic regression analyses were performed to assess factors associated with rifampicin resistance using an adjusted odds ratio at a 95% confidence interval. Statistical significance was considered at a p-value of less than 0.05. Results: A total of 370 presumptive tuberculosis suspects were included; of whom 58.4% were females and the mean age of the participants was 44.3 ± 14 years. Mycobacterium tuberculosis was detected in 63 (17%) (95% confidence interval = 13.2–20.8) suspects. Of these the prevalence of rifampicin-resistant Mycobacterium tuberculosis was 35% (95% confidence interval = 30.2–39.8). Anti-tuberculosis treatment history (adjusted odds ratio = 4.1; 95% confidence interval = 1.91–6.75), monthly income less than $100 USD (adjusted odds ratio = 2.2; 95% confidence interval = 1.77–5.98) and being diagnosed with Asthma (adjusted odds ratio = 2.63; 95% confidence interval = 1.3–7.3) were significantly associated with rifampicin-resistant tuberculosis. Conclusion: A considerable proportion of rifampicin-resistant tuberculosis is reported in these study settings. The strong association between multidrug resistance tuberculosis and patients’ retreatment history of tuberculosis, low income, and co-morbidity with asthma highlights the need for more efforts in tuberculosis treatment and monitoring programs to limit the emergence of multi-drug resistant strain in the study areas.

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“…It damages the lungs and reduces anti-TB treatment efficacy. 39 In the current study, age was not associated with RR-MTB. However, previous studies associated age with RR-MTB.…”

Section: Discussioncontrasting

confidence: 41%

Rifampicin resistant Mycobacterium tuberculosis and associated factors among presumptive pulmonary tuberculosis patients in Mogadishu, Somalia

et al. 2023

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Insights into pathophysiology of dystropy through the analysis of gene networks: an example of bronchial asthma and tuberculosis

et al. 2014

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Co-existence of bronchial asthma (BA) and tuberculosis (TB) is extremely uncommon (dystropic). We assume that this is caused by the interplay between genes involved into specific pathophysiological pathways that arrest simultaneous manifestation of BA and TB. Identification of common and specific genes may be important to determine the molecular genetic mechanisms leading to rare co-occurrence of these diseases and may contribute to the identification of susceptibility genes for each of these dystropic diseases. To address the issue, we propose a new methodological strategy that is based on reconstruction of associative networks that represent molecular relationships between proteins/genes associated with BA and TB, thus facilitating a better understanding of the biological context of antagonistic relationships between the diseases. The results of our study revealed a number of proteins/genes important for the development of both BA and TB.

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Wind-Borne Illness From Coastal Seas

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Asthme et tuberculose : association bénéfique ou maléfique ?

Cited by 4 publications

References 25 publications

Rifampicin resistant Mycobacterium tuberculosis and associated factors among presumptive pulmonary tuberculosis patients in Mogadishu, Somalia

Rifampicin resistant Mycobacterium tuberculosis and associated factors among presumptive pulmonary tuberculosis patients in Mogadishu, Somalia

Insights into pathophysiology of dystropy through the analysis of gene networks: an example of bronchial asthma and tuberculosis

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