Asthma, the sex difference

Kynyk, Jessica; Mastronarde, John G.; McCallister, Jennifer W.

doi:10.1097/mcp.0b013e3283410038

Cited by 161 publications

(131 citation statements)

References 72 publications

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“…Several studies have corroborated these findings in other populations (14). The reasons for this pattern are unknown but hormonal changes at puberty among females may contribute to the increase in genetic susceptibility to the development of asthma (15).…”

Section: Nai North American Indiansupporting

confidence: 64%

Prevalence of and Risk Factors for Asthma in Off-Reserve Aboriginal Children and Adults in Canada

Chang

Beach

2012

Canadian Respiratory Journal

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Only a few studies have investigated asthma morbidity in Canadian Aboriginal children. In the present study, data from the 2006 Aboriginal Peoples Survey were used to determine the prevalence and risk factors for asthma in Canadian Aboriginal children six to 14 years of age and adults 15 to 64 years of age living off reserve. The prevalence of asthma was 14.3% in children and 14.0% in adults. Children and adults with Inuit ancestry had a significantly lower prevalence of asthma than those with North American Indian and Métis ancestries. Factors significantly associated with ever asthma in children included male sex, allergy, low birth weight, obesity, poor dwelling conditions and urban residence. In adults, factors associated with ever asthma varied among Aboriginal groups; however, age group, sex and urban residence were associated with ever asthma in all four Aboriginal groups. The prevalence of asthma was lower in Aboriginal children and higher in Aboriginal adults compared with that reported for the Canadian population. Variation in the prevalence of and risk factors for asthma among Aboriginal ancestry groups may be related to genetic and environmental factors that require further investigation.

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Section: Nai North American Indiansupporting

confidence: 64%

Prevalence of and Risk Factors for Asthma in Off-Reserve Aboriginal Children and Adults in Canada

Chang

Beach

2012

Canadian Respiratory Journal

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“…35 A few studies have described treatments for PMA, with conflicting results. Several small series have described use of leukotriene receptor antagonists, exogenous intramuscular progesterone, xanthines, 14,24 increased doses of inhaled corticosteroids, addition of long-acting beta2 agonists during the second half of the menstrual cycle, oral contraceptives, a single dose of estradiol (2 mg) during the luteal phase and gonadotropin-releasing-hormone (GnRH) analogues. 29 However, more studies are needed in order to determine the appropriate treatment for PMA.…”

Section: Menstrual Cycle and Asthmamentioning

confidence: 99%

“…12 Interestingly, after puberty, the frequency and severity of asthma increase among girls, such that it becomes more common among women by the age of 20 years. 13,14 After the menopause, the difference in asthma prevalence between men and women decreases. 14 Thus, in the United States, 65% of all deaths due to asthma occur among women.…”

Section: Introductionmentioning

confidence: 99%

“…13,14 After the menopause, the difference in asthma prevalence between men and women decreases. 14 Thus, in the United States, 65% of all deaths due to asthma occur among women.…”

Section: Introductionmentioning

confidence: 99%

“…26,27 A relationship between sex hormones and inflammatory responses in the lower airways, especially with regard to asthma, has been observed in several studies. [9][10][11][12][13][14] However, the mechanism for this interaction remains obscure. Thus, it is very important to review the main findings regarding interactions between sex hormones and to understand the pathophysiological mechanisms of this association.…”

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confidence: 99%

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Association between asthma and female sex hormones

Baldaçara

Silva

2017

Sao Paulo Med. J.

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CONTEXT AND OBJECTIVE: The relationship between sex hormones and asthma has been evaluated in several studies. The aim of this review article was to investigate the association between asthma and female sex hormones, under different conditions (premenstrual asthma, use of oral contraceptives, menopause, hormone replacement therapy and pregnancy). DESIGN AND SETTING: Narrative review of the medical literature, Universidade Federal do Tocantins (UFT) and Universidade Federal de São Paulo (Unifesp). METHODS:We searched the CAPES journal portal, a Brazilian platform that provides access to articles in the MEDLINE, PubMed, SciELO, and LILACS databases. The following keywords were used based on Medical Subject Headings: asthma, sex hormones, women and use of oral contraceptives. RESULTS:The associations between sex hormones and asthma remain obscure. In adults, asthma is more common in women than in men. In addition, mortality due to asthma is significantly higher among females. The immune system is influenced by sex hormones: either because progesterone stimulates progesterone-induced blocking factor and Th2 cytokines or because contraceptives derived from progesterone and estrogen stimulate the transcription factor GATA-3. CONCLUSIONS:The associations between asthma and female sex hormones remain obscure. We speculate that estrogen fluctuations are responsible for asthma exacerbations that occur in women. Because of the anti-inflammatory action of estrogen, it decreases TNF-α production, interferon-γ expression and NK cell activity. We suggest that further studies that highlight the underlying physiopathological mechanisms contributing towards these interactions should be conducted. RESUMO CONTEXTO E OBJETIVO:A relação entre os hormônios sexuais e a asma tem sido investigada em diversos estudos. Esta revisão tem como objetivo descrever a relação entre hormônios sexuais (endógenos e exó-genos) e a inflamação nas vias aéreas, especialmente na asma, em eventos diferentes (na asma pré-menstrual, durante o uso de anticoncepcionais, na menopausa, no uso de terapia hormonal e na gestação). TIPO DE ESTUDO E LOCAL:Revisão narrativa da literatura médica, Universidade Federal do Tocantins (UFT) e Universidade Federal de São Paulo (Unifesp). MÉTODO: Pesquisamos o Portal de Periódicos Capes, uma plataforma brasileira que fornece acesso a artigos nas bases de dados MEDLINE, PubMed, SciELO e LILACS. Os descritores utilizados foram asma, hormônios sexuais, mulheres e uso de anticoncepcionais, com base no "Medical Subject Headings". RESULTADOS: As associações entre hormônios sexuais e asma ainda permanecem obscuras. Em adultos, a asma é mais frequente em mulheres do que em homens. Além disso, a mortalidade por asma é significativamente maior no sexo feminino, destacando-se que o sistema imunológico sofre influência de hormônios sexuais, seja porque a progesterona estimula o fator bloqueador induzido pela progesterona e citocinas Th2 ou porque contraceptivos derivados de progesterona e estrógeno estimulam o fator de transcriç...

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The Impact of the US Food and Drug Administration Chlorofluorocarbon Ban on Out-of-pocket Costs and Use of Albuterol Inhalers Among Individuals With Asthma

Jena

Goldman

et al. 2015

JAMA Intern Med

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Asthma, the sex difference

Cited by 161 publications

References 72 publications

Prevalence of and Risk Factors for Asthma in Off-Reserve Aboriginal Children and Adults in Canada

Prevalence of and Risk Factors for Asthma in Off-Reserve Aboriginal Children and Adults in Canada

Association between asthma and female sex hormones

The Impact of the US Food and Drug Administration Chlorofluorocarbon Ban on Out-of-pocket Costs and Use of Albuterol Inhalers Among Individuals With Asthma

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