Asthma Research for All of the United States

Nguyen, Elizabeth A.; Burchard, Esteban G.

doi:10.1089/ped.2012.0173

Cited by 4 publications

(4 citation statements)

References 34 publications

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“…Different populations have different linkage disequilibrium (LD) structures (otherwise known as haploblocks structures), allele frequencies and effect sizes 16 and, thus, single-nucleotide polymorphism (SNP) associations may be population-specific. 17 As a consequence, our current knowledge might be skewed toward the European ancestry–based etiology of atopic disorders, and important genetic and environmental clues to population differences may have been missed. This is because most of the risk alleles and index variants are derived using commercial genotyping arrays ascertained from populations of European ancestry.…”

Section: Atopic Disorders and Racementioning

confidence: 99%

Resolving the etiology of atopic disorders by using genetic analysis of racial ancestry

Gupta

Johansson

Bernstein

et al. 2016

Journal of Allergy and Clinical Immunology

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Atopic dermatitis (AD), food allergy (FA), allergic rhinitis (AR) and asthma are common atopic disorders of complex etiology. The frequently observed “atopic march” from early AD to asthma and/or AR later in life as well as the extensive comorbidity of atopic disorders, suggests common causal mechanisms in addition to distinct ones. Indeed, both disease-specific and shared genomic regions exist for atopic disorders. Their prevalence also varies among races; for example, AD and asthma have a higher prevalence in African-Americans when compared to European-Americans. Whether this disparity stems from true genetic or race-specific environmental risk factors or both is unknown. Thus far, the majority of the genetic studies on atopic diseases have utilized populations of European ancestry, limiting their generalizability. Large cohort initiatives and new analytic methods such as admixture mapping are currently being employed to address this knowledge gap. Here we discuss the unique and shared genetic risk factors for atopic disorders in the context of ancestry variations, and the promise of high-throughput “-omics” based systems biology approach in providing greater insight to deconstruct into their genetic and non-genetic etiologies. Future research will also focus on deep phenotyping and genotyping of diverse racial ancestry, gene-environment, and gene-gene interactions.

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Section: Atopic Disorders and Racementioning

confidence: 99%

Resolving the etiology of atopic disorders by using genetic analysis of racial ancestry

Gupta

Johansson

Bernstein

et al. 2016

Journal of Allergy and Clinical Immunology

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“…Discrepancies exist between Latino subgroups as well, with asthma disproportionately affecting Puerto Ricans (PR) (5). Among children (<18 years), PR have the highest documented asthma prevalence (18.7%) and mortality (40.9 per million) and Mexicans have the lowest prevalence (4.8%) and mortality (9.2 per million) (6, 7).…”

Section: Introductionmentioning

confidence: 99%

The effect of parental social support and acculturation on childhood asthma control

2015

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Objective There exists large ethnic disparities in asthma among Latino children; Puerto Ricans (PR) are disproportionately affected, while Mexicans have the lowest prevalence and morbidity. Disparities are poorly understood, however, acculturation and social support are suggested to influence asthma control among children. This study investigated the relationship between acculturation, social support, and asthma control among PR and Mexican children and their caregivers. Methods Primary caregiver-child dyads (N=267) of PR (n=79) and Mexican (n=188) descent were recruited from clinics at two inner-city hospitals in Bronx, NY and three clinics in Phoenix, AZ. Children were 5-12 years of age and had a confirmed asthma diagnosis. Dyads completed measures of social support, acculturation and asthma control; logistic regression was used for analysis. Results Mexican children had better asthma control than PR children (p<.001). PR caregivers were more acculturated than Mexican caregivers (p<.05); however, acculturation did not predict control. Across Latino subgroups caregivers’ total level of social support predicted better asthma control among children (p<.05), and support received from family and friends each independently predicted better control (p<.05). Conclusions Results suggest that social support reduces some of the burden associated with asthma management enabling caretakers to better control their children’s asthma.

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“…Chaldean and Arab individuals have a lower prevalence of asthma than non-Middle Eastern white and African American individuals [ 82 ]. A great deal of evidence has suggested that genetic variation and gene–environment interactions are moderately accountable for the ethnic discrepancy in asthma morbidity and prevalence [ 83 , 84 ]. As discussed above, the negative association between PTVM and asthma prevalence possibly results from the relatively short residence time and low asthma-related genes of visible minorities in Toronto compared with non-minorities.…”

Section: Discussionmentioning

confidence: 99%

Association between Green Space Structure and the Prevalence of Asthma: A Case Study of Toronto

Dong

Liu

Zheng

2021

IJERPH

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Asthma is a chronic inflammatory disease that can be caused by various factors, such as asthma-related genes, lifestyle, and air pollution, and it can result in adverse impacts on asthmatics’ mental health and quality of life. Hence, asthma issues have been widely studied, mainly from demographic, socioeconomic, and genetic perspectives. Although it is becoming increasingly clear that asthma is likely influenced by green spaces, the underlying mechanisms are still unclear and inconsistent. Moreover, green space influences the prevalence of asthma concurrently in multiple ways, but most existing studies have explored only one pathway or a partial pathway, rather than the multi-pathways. Compared to greenness (measured by Normalized Difference Vegetation Index, tree density, etc.), green space structure—which has the potential to impact the concentration of air pollution and microbial diversity—is still less investigated in studies on the influence of green space on asthma. Given this research gap, this research took Toronto, Canada, as a case study to explore the two pathways between green space structure and the prevalence of asthma based on controlling the related covariates. Using regression analysis, it was found that green space structure can protect those aged 0–19 years from a high risk of developing asthma, and this direct protective effect can be enhanced by high tree diversity. For adults, green space structure does not influence the prevalence of asthma unless moderated by tree diversity (a measurement of the richness and diversity of trees). However, this impact was not found in adult females. Moreover, the hypothesis that green space structure influences the prevalence of asthma by reducing air pollution was not confirmed in this study, which can be attributed to a variety of causes.

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Asthma Research for All of the United States

Cited by 4 publications

References 34 publications

Resolving the etiology of atopic disorders by using genetic analysis of racial ancestry

Resolving the etiology of atopic disorders by using genetic analysis of racial ancestry

The effect of parental social support and acculturation on childhood asthma control

Association between Green Space Structure and the Prevalence of Asthma: A Case Study of Toronto

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