Asthma progression: Can we and should we measure it?

Injury and Repair

“…[381][382][383] These studies support the concept that failure to establish or maintain an appropriately sized pool of facultative progenitor cells fosters environmentally induced chronic injury and dysfunctional repair cycles characteristic of lung disease. The lung undergoes rapid and extensive maturation during the postnatal period.…”

Children’s Urinary Phthalate Metabolites and Fractional Exhaled Nitric Oxide in an Urban Cohort

“…The methodology for measuring FE NO allows for noninvasive collection and measurement of NO produced by resident airway cells in response to inflammatory cytokines and mediators (37). Although its diagnostic use in children remains debated (37,38), FE NO has been established as a biomarker of airway inflammation in response to air pollutants, with more than a decade of epidemiology studies (20,22,23,39,40). In population-based studies, the majority of subjects with asthma have mild disease with infrequent exacerbations, making temporal associations between environmental exposures and exacerbations difficult to establish.…”

Rhinitis and asthma represent hot topics for Allergy

“…Airway remodeling is another important topic and it is needed to differentiate persistence vs progression (28–30). The treatment of severe asthma by anti‐IgE is still a hot topic (31–33) including the cost‐effectiveness of expensive interventions (34).…”