Asthma Mortality in Male Workers of the Dye Industry in Korea

Koh, Dong Hee; Won, Jong Yun; Ahn, Yeon Soon; Kim, Hyoung Ryoul; Koh, Sang Beak

doi:10.1539/joh.l7128

Cited by 6 publications

(6 citation statements)

References 18 publications

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“…Other dye‐induced cell damage may require repeated, or even chronic, exposures. Immunological hypersensitivity resulting from respiratory exposure to reactive dyes, for instance, involves a minimum of two dye exposure events . Another general topic is the type of damage induced.…”

Section: How Does All This Relate To Toxicity?mentioning

confidence: 99%

Where do dyes go inside living cells? Predicting uptake, intracellular localisation, and accumulation using QSAR models

Horobin

2014

Coloration Technology

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Uptake of dyes into living cells and organisms is of concern to several diverse groups of people. These include those not wishing dyes to enter cells (e.g. manufacturers and users of textile dyes, or laboratory workers using dyes as analytical reagents) and those requiring dye entry (e.g. biologists imaging cell contents, or clinicians using photoactive dyes as antitumour drugs). This diversity results in the need to consider an extremely wide range of dyes -and indeed of cells and organisms. An overview of methods for predicting uptake and intracellular localisation is provided, followed by a more detailed account of the concepts and procedures involved in decision-rule quantitative structure-activity relationship (QSAR) models. Some of these models permit the prediction of which dyes are likely to enter cells, and which dyes will be excluded. Other models predict where internalised dyes will localise within the live cells. Use of QSAR models to understand intracellular accumulation, redistribution, loss from the cell, and metabolic modification of dyes is also considered. In particular, the relationship of such predictions to toxicity is discussed. An extended case example is provided, describing the modelling of dye binding to nucleic acids in single-cell systems. A further case example then illustrates dye localisation in multicellular organisms. Finally, conclusions, critiques, and probable future directions concerning the QSAR modelling approach to dye uptake and localisation are given. A summary of key QSAR decision rules in the form of decision logic tabulations is provided.

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Section: How Does All This Relate To Toxicity?mentioning

confidence: 99%

Where do dyes go inside living cells? Predicting uptake, intracellular localisation, and accumulation using QSAR models

Horobin

2014

Coloration Technology

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“…In Korea, manufacturing workers exposed to specific hazardous agents such as benzene and noise must undergo particular health examinations on an annual basis 7. For example, foundry workers exposed to fume and high noise concurrently must undergo medical tests such as chest x-ray and pure tone audiometry.…”

Section: Methodsmentioning

confidence: 99%

The risk of hospitalisation for infectious pneumonia in mineral dust exposed industries: Table 1

Koh

Moon

Jeongyoun³

et al. 2010

Occup Environ Med

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“…Various dyestuffs are considered to be causes of occupational respiratory diseases, which are mainly described in workers in textile and cosmetic industries [3][4][5][6][7][8][9][10][11]. Azoic dyes, which are synthesized from primary aromatic amines, are the most extensively used synthetic organic colorants worldwide [12].…”

Section: Introductionmentioning

confidence: 99%

Sudan red dye: a new agent causing type-2 occupational asthma

Clofent

Homdedeu

Muñoz-Esquerre

et al. 2020

Allergy Asthma Clin Immunol

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Background: Sudan red or 1-[(2-methoxyphenyl)azo]-2-naphthol is a low molecular weight azoic agent widely used in industry, particularly in the production of hair dyes. The use of this product in the food industry is prohibited due to its potential carcinogenic effect, but no respiratory involvement has been reported to date. Case presentation:We present the case of a 46-year-old female patient who had been working in a cosmetics packaging company for 20 years. The patient developed occupational asthma to a red azo dye known as Sudan red. The diagnosis was confirmed by specific bronchial provocation test. Induced sputum samples were obtained previously and in the 24 h following the procedure, with a rise in the percentage of eosinophils from 10 to 65%. Conclusions:This report describes the case of a patient who developed OA caused by exposure to an azoic dye called Sudan red. The clinical and analytical features suggest a type 2-related asthma; however, we are not yet able to confirm the specific pathophysiological mechanism. The extensive use of azo dyes in industry means that it is particularly important to describe their implications for health, which are probably underestimated at present.

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Asthma Mortality in Male Workers of the Dye Industry in Korea

Cited by 6 publications

References 18 publications

Where do dyes go inside living cells? Predicting uptake, intracellular localisation, and accumulation using QSAR models

Where do dyes go inside living cells? Predicting uptake, intracellular localisation, and accumulation using QSAR models

The risk of hospitalisation for infectious pneumonia in mineral dust exposed industries: Table 1

Sudan red dye: a new agent causing type-2 occupational asthma

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