Asthma medication use in pregnancy and fetal growth

Effect of maternal asthma on the risk of specific congenital malformations: A population‐based cohort study

“…A recent review article reported that induced fetal hypoxia in mammalian embryos and other animal embryos has been associated with defects such as transverse limb reduction, cleft lip and heart defects (Webster and Abela, 2007). In human studies, women with asthma with severe or uncontrolled asthma and those requiring acute care for asthma during pregnancy were found to be at increased risk of congenital malformations and this has been attributed to decreased fetal blood oxygen (Bakhireva et al, 2005;Blais and Forget, 2008). These two studies have provided useful information, but neither of them considered specific congenital malformations.…”

Safety of leukotriene receptor antagonists in pregnancy

“…The detailed methodology of this study has been described elsewhere. 11,12 Briefly, OTIS is a nonprofit organization of teratology information services located across North America that receives calls from approximately 100,000 women a year with questions about various exposure factors in pregnancy. The Asthma Medications in Pregnancy Study was designed to evaluate the safety of inhaled corticosteroids in pregnancy utilizing OTIS network.…”

Control and severity of asthma during pregnancy are associated with asthma incidence in offspring: two-stage case-control study

“…Using this definition of maternal asthma, the mother might or might not have had asthma during pregnancy. The monitoring of the asthma status during pregnancy is important, as associations have been reported between the increased asthma severity and/or lack of maternal asthma control during pregnancy and perinatal mortality and low birthweight [9][10][11][12][13], whereas inconsistent associations have also been reported for prematurity and intra-uterine growth restriction [13][14][15][16].…”