Asthma management and control in children, adolescents, and adults in 25 countries: a Global Asthma Network Phase I cross-sectional study

García‐Marcos, Luis; Chiang, Chifa; Asher, M. Innes; Marks, Guy B.; Sony, Asma El; Bissell, Karen; Ellwood, Eamon; Ellwood, Philippa; Pearce, Neil; Strachan, David P.; Mortimer, Kevin; Morales, Eva; Ahmetaj, Luljeta; Ajeagah, Gideon Aghaindum; Alkhayer, Ghroob; Alomary, Shaker A.; Ambriz-Moreno, Maria J.; Arias-Cruz, Alfredo; Awasthi, Sanjay; Badellino, Héctor; Behniafard, Nasrin; Bercedo-Sanz, Alberto; Brożek, Grzegorz; Bucaliu-Ismajli, Ibadete; Cabrera-Aguilar, Angela; Chinratanapisit, Sasawan; Del-Río-Navarro, Blanca E.; Douros, Konstantinos; Sadig, Hana El; Escalante-Domínguez, Alberto José; Falade, A G; Gacaferri-Lumezi, Besa; García‐Almaráz, Roberto; Garcia-Muñoz, Rosa; Ghashi, Valbona; Ghoshal, Aloke Gopal; González-Díaz, Carlos; Hana-Lleshi, Leonora; Hernández-Mondragón, Luis Octavio; Huang, Jing‐Long; Jiménez-González, Carlos Adrián; Juan-Pineda, M. Ángeles; Kochar, Sanjay Kumar; Kuzmicheva, Kseniiay; Linares‐Zapién, Francisco Javier; Lokaj-Berisha, Violeta; López-Silvarrey, Angel; Lozano-Sáenz, José Santos; Mahesh, P A; Mallol, Javier; Martinez-Torres, Antonia E.; Masekela, Refiloe; Mérida-Palacio, J. Valente; Mohammad, Yousser; Moreno-Gardea, Héctor Leonardo; Navarrete-Rodríguez, Elsy Maureen; Ndikum, Achiri E.; Nour, Magde Mohamed; Ochoa-López, Georgina; Pajaziti, Laura; Pellegrini-Belinchón, J.; Pérez‐Fernández, Virginia; Priftis, Kostas Ν.; Ramos-García, Beatriz C.; Ranasinghe, Jagath C.; Robertson, Stephen; Rodríguez-Pérez, Noel; Rutter, Charlotte E; Sacre-Hazouri, José Antonio; Salvi, Sundeep; Sanchez, Javier F.; Sánchez, José Félix Baselga; Sánchez-Coronel, María Guadalupe; Saucedo-Ramírez, Omar Josué; Singh, Meenu; Singh, Nishtha; Singh, Virendra; Sinha, Sanjeev; Sit, Niranjan; Sosa-Ferrari, Suyapa M.; Soto-Martínez, Manuel; Urrutia-Pereira, Marylin; Yeh, Kuo‐Wei; Zar, Heather J.; Zhjeqi, Valbona

doi:10.1016/s2214-109x(22)00506-x

Cited by 38 publications

(15 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Surveillance at a global level is also fundamental in establishing how allergic diseases are managed and identifying the needs of countries with lower income in enabling access to the right medicines. Although we have guidelines for treatment everywhere, it is recognized that they are not followed in many instances ( 10 ) for several reasons, including the lack of affordability in low-resource settings ( 11 ). Is there a way that patients with severe disease can obtain access to biological treatments in low-income countries?…”

Section: Epidemiologymentioning

confidence: 99%

Grand challenges in genetics and epidemiology of allergic diseases: from genome to exposome and back

Garcia-Marcos

2024

Front. Allergy

View full text Add to dashboard Cite

Section: Epidemiologymentioning

confidence: 99%

Grand challenges in genetics and epidemiology of allergic diseases: from genome to exposome and back

Garcia-Marcos

2024

Front. Allergy

View full text Add to dashboard Cite

“…2 Bronchial asthma is one of the most common noncommunicable diseases throughout the life span, impacting more than 350 million children, adolescents and adults worldwide. 3 It mainly occurs in young children and has an 8%-28% incidence and prevalence globally, and it is increasing yearly. 4 In Egypt, the prevalence of asthma among school children in the Nile Delta region is about 7.7% 5 with probably underdiagnosis and undertreatment, particularly among children from less wealthy families.…”

Section: Introduction and Scopementioning

confidence: 99%

A protocol for adapting a clinical practice guideline for the treatment of paediatric asthma for the Egyptian Pediatric Clinical Practice Guidelines Committee

Abdel Baky,

Youssef,

Elsholkamy

et al. 2024

Clinical and Public Health Guidelines

View full text Add to dashboard Cite

IntroductionPaediatric asthma is a prevalent and chronic respiratory condition affecting children worldwide. This protocol outlines the methodology for developing a clinical practice guideline (CPG) for the management of paediatric asthma. The goal of this guideline is to provide evidence‐based recommendations for healthcare professionals, improving the quality of care and health outcomes for paediatric patients with asthma.MethodsWe will use the ‘Adapted ADAPTE’ adaption method, a systematic approach to adapt existing guidelines, which consists of three phases (setup, adaptation and finalisation phases), nine modules and 24 steps, with adaptations to the process and tools to suit the Egypt healthcare context and resources.QuestionsClinical questions were prepared using the patient population, interventions, professionals, outcomes and healthcare context (PIPOH) model. This CPG protocol addresses critical clinical questions at the heart of effective asthma management in children. It focuses on the diagnosis of paediatric asthma, considering age‐specific clinical presentations and diagnostic tests, assessment of asthma severity, control medications like inhaled corticosteroids, long‐acting β‐agonists and others, with an emphasis on appropriate tools and criteria. The CPG also delves into the realm of long‐term control treatment, exploring the effectiveness and safety of pharmacological and nonpharmacological interventions, while considering individualised needs. Furthermore, it examines strategies for monitoring and adjusting treatment plans over time, ensuring optimal care. These clinical questions form the foundation of the CPG, facilitating evidence‐based care delivery and enhancing health outcomes for paediatric asthma patients.

show abstract

“…In 2019, an estimated 12,900 deaths occurred and 5.1 million disability-adjusted life years were lost due to childhood asthma ( Zhang and Zheng, 2022 ). According to the latest global report, only 44.1% of children and 55.4% of adolescents with asthma achieved a well-controlled disease stage ( García-Marcos et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Impact of treatment adherence and inhalation technique on asthma outcomes of pediatric patients: a longitudinal study

Lizano-Barrantes,

Garin,

Mayoral

et al. 2024

Front. Pharmacol.

Self Cite

View full text Add to dashboard Cite

Introduction: We aimed to evaluate the longitudinal relationships, both at between- and within-person levels, that adherence to inhaled corticosteroid-based maintenance treatment and inhalation technique present with symptom control, exacerbations, and health-related quality of life (HRQoL) in children and adolescents with asthma.Methods: Participants (6–14 years old) from the ARCA (Asthma Research in Children and Adolescents) cohort—a prospective, multicenter, observational study (NCT04480242)—were followed for a period from 6 months to 5 years via computer-assisted telephone interviews and a smartphone application. The Medication Intake Survey–Asthma (MIS-A) was administered to assess the implementation stage of adherence, and the Inhalation Technique Questionnaire (InTeQ) was used to assess the five key steps when using an inhaler. Symptom control was measured with the Asthma Control Questionnaire (ACQ), and HRQL was measured with the EQ-5D and the Patient-Reported Outcomes Measurement Information System–Pediatric Asthma Impact Scale (PROMIS-PAIS). Multilevel longitudinal mixed models were constructed separately with symptom control, exacerbation occurrence, EQ-5D, and PROMIS-PAIS as the dependent variables.Results: Of the 360 participants enrolled, 303 (1,203 interviews) were included in the symptom control and exacerbation analyses, 265 (732) in the EQ-5D, and 215 (617) in the PROMIS-PAIS. Around 60% of participants were male subjects, and most of them underwent maintenance treatment with inhaled corticosteroids plus long-acting β-agonists in a fixed dose (73.3%). Within-person variability was 83.6% for asthma control, 98.6% for exacerbations, 36.4% for EQ-5D, and 49.1% for PROMIS-PAIS. At the within-person level, patients with higher adherence had better symptom control (p = 0.002) and HRQoL over time (p = 0.016). Patients with a better inhalation technique reported worse HRQoL simultaneously (p = 0.012), but they showed better HRQoL in future assessments (p = 0.012). The frequency of reliever use was associated with symptom control (p < 0.001), exacerbation occurrence (p < 0.001), and HRQoL (p = 0.042); and boys were more likely to present better symptom control and HRQoL than girls.Conclusion: Our results confirm longitudinal associations at the within-person level of the two indicators of quality use of inhalers: for adherence to maintenance treatment with symptom control and HRQoL, and for the inhalation technique with HRQoL. Although treatment adherence was shown to be excellent, a third of the participants reported a suboptimal inhalation technique, highlighting the need for actions for improving asthma management of the pediatric population.

show abstract

Asthma management and control in children, adolescents, and adults in 25 countries: a Global Asthma Network Phase I cross-sectional study

Cited by 38 publications

References 27 publications

Grand challenges in genetics and epidemiology of allergic diseases: from genome to exposome and back

Grand challenges in genetics and epidemiology of allergic diseases: from genome to exposome and back

A protocol for adapting a clinical practice guideline for the treatment of paediatric asthma for the Egyptian Pediatric Clinical Practice Guidelines Committee

Impact of treatment adherence and inhalation technique on asthma outcomes of pediatric patients: a longitudinal study

Contact Info

Product

Resources

About