Asthma in the Elderly

Lee, H. Y.; Stretton, T. B.

doi:10.1136/bmj.4.5832.93

Cited by 50 publications

(26 citation statements)

References 11 publications

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“…In addition, it was reported that smoking asthmatics were resistant to inhaled corticosteroid [15]. Indeed, a close association between asthma and smoking has been reported as a characteristic of elderly asthmatics [16]. These findings indicate that some elderly asthmatics with initially low airway responsiveness might have increased the responsiveness through a long history of smoking.…”

Section: Discussionmentioning

confidence: 51%

Multiple Logistic Regression Analysis of Risk Factors for the Development of Steroid-Dependent Asthma in the Elderly: A Comparison with Younger Asthmatics

Ishioka

Terada²,

Haruta³

et al. 2001

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Background: The percentage of the aged among all patients with bronchial asthma is increasing. Objective: To investigate the risk factors for the development of steroid-dependent asthma in the elderly. Methods: A multiple logistic regression analysis involving various clinical factors between steroid-dependent and -independent asthma was carried out for 59 asthmatics aged over 60 years, including 16 patients with steroid-dependent asthma. The calculated risk for each factor was compared with that obtained from 122 younger asthmatics aged 20–59 years. Results: Among the factors examined (sex, age, period from onset of asthma, type of asthma and family history of asthma, plus history of smoking, atopic dermatitis, allergic rhinitis, chronic sinusitis and nasal polyps), the significant risk factors for the development of steroid dependency in the elderly asthmatics were only family history of bronchial asthma (relative risk 3.6) and smoking history (relative risk 6.9). Conclusions: Some risk factors for steroid-dependent asthma in younger individuals were not significant in the elderly. Since the smoking history was most closely associated with the development of steroid dependency in the elderly, even though most of them had quit smoking, it is important for patients with asthma to avoid smoking.

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Section: Discussionmentioning

confidence: 51%

Multiple Logistic Regression Analysis of Risk Factors for the Development of Steroid-Dependent Asthma in the Elderly: A Comparison with Younger Asthmatics

Ishioka

Terada²,

Haruta³

et al. 2001

Respiration

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“…Few studies described asthma onset at ages 65+ and available studies are often limited by small numbers of patients and a tendency to group all patients older than 55 or 60 years old as a single category [38][39][40][41]. Age-and sex-specific incidence rates for definite and probable asthma per 100,000 person-years were analyzed in a populationbased study in Rochester, Minnesota, for 1964-1983 [42]: incidence rates decreased with age the same way as in our study; however, the absolute incidence rates were lower than those obtained from our analysis-so, the rates were about 140 for males and 80 for females at ages 65-74, 110 for males and 70 for females at ages 75-84, and about 60 for males and 50 for females at ages 85+.…”

Section: Asthmamentioning

confidence: 99%

Population-Based Analysis of Incidence Rates of Cancer and Noncancer Chronic Diseases in the US Elderly Using NLTCS/Medicare-Linked Database

et al. 2013

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The age, disability, and comorbidity patterns of incidence rates of cancer and chronic noncancer diseases such as heart failure, diabetes mellitus, asthma, Parkinson's disease, Alzheimer's disease, skin melanoma, and cancers of breast, prostate, lung, and colon were studied for the US elderly population (aged 65+) using the National Long-Term Care Survey (NLTCS) data linked to Medicare records for 1991-2005. Opposite to breast cancer and asthma, incidence rates of heart failure and Alzheimer's diseases were increasing with age. Higher incidence rates of heart failure, diabetes, asthma, and Parkinson's and Alzheimer's diseases were observed among individuals with severe disabilities or/and comorbidities, while rates of breast and prostate cancers were higher among those with minor disabilities or fewer comorbidities. Our results were in agreement with those obtained from other epidemiological datasets, thus suggesting that Medicare administrative records can provide nationally representative incidence rates. Detailed sensitivity analysis that focused on the effects of alternative onset definitions, latent censoring, study design, and other procedural uncertainties showed the stability of reconstructed incidence rates. This Medicare-linked dataset can be used for studying highly debated effects of new medical technologies on aging-related diseases burden and future Medicare costs.

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“…Even when high prevalence of smoking (which increases diagnostic difficulties) [3] or the small number of patients [2,4] may confuse their results, there is evidence suggesting that frequency and severity of symptoms are different among older patients.…”

Section: Introductionmentioning

confidence: 99%

Is Asthma in the Elderly Really Different?

Quadrelli

Aj²

1998

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To examine the nature of asthma in the elderly, we compared older (group 1: 65 years or older, n = 50) with younger patients (group 2: <40 years, n = 99) and to determine the influence of long-standing disease, elderly asthmatics with early onset (group A: onset before 40, n = 22) were compared with patients developing symptoms later in their lives (group B: onset after 40, n = 22). Blood eosinophilia and IgE value >/=100 IU/l were more frequent in younger patients. Short symptom-free periods were more frequent among older asthmatics (78.5 vs. 45.4%, p < 0.001). Only 31.2% of older patients had only mild symptoms. Requirement of systemic steroids was higher in the elderly population. The worst FEV1 was lower in older patients (54.4 +/- 17.3 vs. 71.8 +/- 18.5%, p

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Asthma in the Elderly

Cited by 50 publications

References 11 publications

Multiple Logistic Regression Analysis of Risk Factors for the Development of Steroid-Dependent Asthma in the Elderly: A Comparison with Younger Asthmatics

Multiple Logistic Regression Analysis of Risk Factors for the Development of Steroid-Dependent Asthma in the Elderly: A Comparison with Younger Asthmatics

Population-Based Analysis of Incidence Rates of Cancer and Noncancer Chronic Diseases in the US Elderly Using NLTCS/Medicare-Linked Database

Is Asthma in the Elderly Really Different?

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