Asthma in the Elderly

Rogers, Linda; Cassino, Cara; Berger, Kenneth I.; Goldring, Roberta M.; Norman, Robert G.; Klugh, Thomas; Reibman, Joan

doi:10.1378/chest.122.5.1580

Cited by 63 publications

(16 citation statements)

References 20 publications

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“…Rogers et al reported that in an asthma clinic in New York City , that 60% of subjects > 65 years of age had at least one detectable allergen specific IgE (including outdoor allergens) and that cockroach sensitization was the most prevalent at 47% [94]. Cockroach sensitization was associated with more severe asthma as determined by airflow limitation and hyperinflation.…”

Section: The Aging Lung: the Role Of The Inflammatory Allergic And Imentioning

confidence: 99%

“…The most common aeroallergen to which older patients with asthma are sensitized is not consistent among reports, but includes cat [93], dust mites [92,95], and cockroach [94]. Whether the differences in specific antigen sensitization are due to socioeconomic status, geographic location and environmental exposures, is not well established at the present.…”

Section: The Aging Lung: the Role Of The Inflammatory Allergic And Imentioning

confidence: 99%

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Asthma in the elderly: what we know and what we have yet to know

Yáñez

Cho

Soriano³

et al. 2014

World Allergy Organization Journal

112

120

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In the past, asthma was considered mainly as a childhood disease. However, asthma is an important cause of morbidity and mortality in the elderly nowadays. In addition, the burden of asthma is more significant in the elderly than in their younger counterparts, particularly with regard to mortality, hospitalization, medical costs or health-related quality of life. Nevertheless, asthma in the elderly is still been underdiagnosed and undertreated. Therefore, it is an imperative task to recognize our current challenges and to set future directions. This project aims to review the current literature and identify unmet needs in the fields of research and practice for asthma in the elderly. This will enable us to find new research directions, propose new therapeutic strategies, and ultimately improve outcomes for elderly people with asthma. There are data to suggest that asthma in older adults is phenotypically different from young patients, with potential impact on the diagnosis, assessment and management in this population. The diagnosis of AIE in older populations relies on the same clinical findings and diagnostic tests used in younger populations, but the interpretation of the clinical data is more difficult. The challenge today is to encourage new research in AIE but to use the existing knowledge we have to make the diagnosis of AIE, educate the patient, develop a therapeutic approach to control the disease, and ultimately provide a better quality of life to our elderly patients.

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Section: The Aging Lung: the Role Of The Inflammatory Allergic And Imentioning

confidence: 99%

Section: The Aging Lung: the Role Of The Inflammatory Allergic And Imentioning

confidence: 99%

Asthma in the elderly: what we know and what we have yet to know

Yáñez

Cho

Soriano³

et al. 2014

World Allergy Organization Journal

112

120

View full text Add to dashboard Cite

show abstract

“…Rogers et al demonstrated in a study of 45 patients > 65 years of age recruited from an asthma clinic in New York City, that 60% had at least one detectable allergen specific IgE (including outdoor allergens) and 47% were sensitized to cockroach. (125) Among these patients, cockroach sensitization was associated with more severe asthma as measured by airflow limitation and hyperinflation. However, this study did not compare rates of sensitization of elderly versus younger asthmatics.…”

Section: Age-related Changes In Adaptive Immunitymentioning

confidence: 94%

“…Another study looked at adult inner-city patients with moderate to severe persistent asthma, and found that 41% of those greater than 60 years of age were sensitized to at least one antigen, whereas 73% between 18-35 years of age were sensitized. (126) The most common aeroallergen to which older patients are sensitized is not consistent among reports and has been cat, (124) dust mites, (123;126) and cockroach (125) . Whether the differences in specific antigen sensitization are due to socioeconomic status, geographic location and environmental exposures, is not well established.…”

Section: Age-related Changes In Adaptive Immunitymentioning

confidence: 96%

Age-related changes in immune function: Effect on airway inflammation

Busse¹,

Mathur²

2010

Journal of Allergy and Clinical Immunology

158

141

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Immunosenescence is defined as changes in the innate and adaptive immune response associated with increased age. The clinical consequences of immunosenescence include increased susceptibility to infection, malignancy, and autoimmunity, decreased response to vaccination and impaired wound healing. However, there are several immune alterations which may facilitate persistence of asthma into late adulthood, or development of asthma after the age of 50-60 years. Asthma in older patients is not uncommon and is a growing population as the average lifespan increases. Specific innate changes which may affect severity of asthma in older patients, or be involved in the development of late onset asthma include impaired in mucociliary clearance, and changes in airway neutrophil, eosinophil and mast cell numbers and function. Additionally, age-related altered antigen presentation and decreased in specific antibody responses may increases the risk of respiratory infections. Respiratory infections exacerbate asthma in older patients, and possibly play a role in the pathogenesis of late onset asthma. Furthermore, cytokine profiles may be modified with aging; some investigators suggesting a trend towards Th2 cytokine expression. This review examines specific innate and adaptive immune responses affected by aging that may impact the inflammatory response in older adults with asthma.

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“…During the years 2004-2009, asthma severity increased with increasing sensitization to mite and mite plus cockroach. In another study conducted in a population of elderly urban patients with asthma, the presence of cockroach-specific serum IgE was associated with more severe asthma, as reflected by an increase in airway obstruction and hyperinflation [75]. In a Polish study it was observed that the concentration of Bla g 2 in houses was higher than previously reported in other European countries, and children with cockroach hypersensitivity had more often severe asthma than children with other allergies [76].…”

Section: Cockroach Allergens Sensitization and Severe Asthmamentioning

confidence: 99%

Is allergic sensitization relevant in severe asthma? Which allergens may be culprits?

Lombardi

Savi

Ridolo

et al. 2017

World Allergy Organization Journal

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Severe asthma is a major health concern. The allergic (IgE-mediated) form of asthma is well known from a pathogenic viewpoint. We searched the available literature to identify which allergens are most frequently associated with severe, refractory or life threatening asthma. According to the results, molds, pet dander, cockroach and ragweed were more frequently responsible for severe asthma. Thunderstorm asthma, in addition, represents a special association between allergic sensitization and an external climatic factor. A detailed knowledge of the most harmful allergens is mandatory for an appropriate diagnostic and preventive approach.

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Asthma in the Elderly

Cited by 63 publications

References 20 publications

Asthma in the elderly: what we know and what we have yet to know

Asthma in the elderly: what we know and what we have yet to know

Age-related changes in immune function: Effect on airway inflammation

Is allergic sensitization relevant in severe asthma? Which allergens may be culprits?

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