Asthma, Family History of Drug Allergy, and Age Predict Amoxicillin Allergy in Children

Faitelson, Yoram; Boaz, Mona; Dalal, Ilan

doi:10.1016/j.jaip.2017.11.015

Cited by 23 publications

(38 citation statements)

References 30 publications

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“…83 In children, STs have not shown clinical value in IR and NIR to amoxicillin. 84 However, in a retrospective study, STs have demonstrated a PPV of 99.4%, indicating their usefulness, before DPT. 85 Large multicentre studies, to evaluate the real diagnostic predictive values of ST, are needed.…”

Section: In Vivo Testsmentioning

confidence: 95%

Recent developments and highlights in drug hypersensitivity

Mayorga

Fernandez

Montañez

et al. 2019

Allergy

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Drug hypersensitivity reactions (DHRs) are nowadays the third cause of allergy after rhinitis and asthma with a significant increase in prevalence in both adults and paediatric population with new drugs included as culprit. For this, DHRs represent not only a health problem but also a significant financial burden for affected individuals and health systems. Mislabelling DHRs is showing to be a relevant problem for both, false label of drug allergic and false label of nonallergic. All this reinforces the need to improve accurate diagnostic approaches that allow an appropriate management.Moreover, there is a need for training both, nonallergist stakeholders and patients to improve the reaction identification and therefore decrease the mislabelling. The use of allergy cards has shown to be relevant to avoid the induction of DHRs due to the prescription of wrong medication.Recent developments over the last 2 years and highlights about risk factors, diagnostic approaches, mechanisms involved as well as prevention actions, and management have been reviewed. In these papers, it has been outlined the need for correct diagnosis and de-labelling of patients previously false-reported as allergic, which will improve the management and treatment of patients with DHRs. K E Y W O R D Sallergy diagnosis, allergy treatment, basic mechanisms, drug allergy, epidemiology | 2369

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Section: In Vivo Testsmentioning

confidence: 95%

Recent developments and highlights in drug hypersensitivity

Mayorga

Fernandez

Montañez

et al. 2019

Allergy

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“…No significant relation was observed with a personal and family history of allergy, as in the study by Ponvert et al, 13 but unlike the one by Faitelson et al 10 Few diagnostic confirmation studies have been published and, in general, amoxicillin allergy is over-diagnosed. 14 underlines the importance of patient questioning and diagnostic tests to prevent the negative impact of classifying patients with a non-existent condition.…”

Section: Discussionmentioning

confidence: 75%

“…Patients were considered to have a high risk for allergy if they were older than 12 years of age and/or had a history of severe events (visit to the emergency department, respiratory distress symptoms and/or adrenaline use). 10 In these patients, if the ELISA test was negative, an SPT and a IDR skin test were done; patients considered to have a low risk had a challenge test done immediately after the negative ELISA test.…”

Section: Atopy Patch Test (Apt)mentioning

confidence: 99%

Diagnostic confirmation of amoxicillin allergy in children treated at a division of Pediatric Allergy

et al. 2020

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Amoxicillin is a beta-lactam antibiotic commonly indicated in pediatrics and the most frequent cause of drug allergies. Objectives. To determine the proportion of confirmed amoxicillin allergy in children with diagnostic suspicion seen at the Division of Pediatric Allergy. Population and methods. This descriptive, retrospective study was done between January 2009 and January 2017 in children younger than 18 years with diagnostic suspicion of amoxicillin allergy. The diagnosis was based on questions and specific tests. Results. A total of 234 patients were included; amoxicillin allergy was diagnosed in 10.7 % (95 % confidence interval: 7-15). These patients had a higher prevalence of immediate symptoms (40 % vs. 22 %, p = 0.048) and prior exposure to beta-lactams (84 % vs. 56 %, p = 0.007). Conclusion. Amoxicillin allergy in children referred to specialists was confirmed in 10.7 %.

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“…No se encontró una relación significativa entre los antecedentes personales y familiares de alergia, al igual que el estudio de Ponvert y col., 13 y a diferencia del de Faitelson y col. 10 Existen pocos estudios de confirmación diagnóstica y, en general, un sobrediagnóstico de esta afección. 14 Este trabajo aborda un problema para el cual no hay suficientes datos y subraya la importancia del interrogatorio y las pruebas diagnósticas para evitar el impacto negativo que genera categorizar a los pacientes con una afección inexistente.…”

Section: Discussionunclassified

“…Se consideraron pacientes con alto riesgo de alergia los mayores de 12 años y/o con historia de episodios graves (consulta a la central de emergencias, síntomas de dificultad respiratoria y/o uso de adrenalina). 10 A estos pacientes, si el resultado del ELISA fue negativo, se les realizaron las PCLI e intradermorreacción; a los pacientes considerados de bajo riesgo se les realizó directamente el test de provocación después del ELISA negativo.…”

Section: Población Y Métodosunclassified

Confirmación diagnóstica de alergia a la amoxicilina en niños tratados en una sección de alergia pediátrica

2020

Arch Argent Pediat

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Comunicaciones breves RESUMEN La amoxicilina es un antibiótico betalactámico comúnmente indicado en pediatría y es la causa más frecuente de alergia a medicamentos. Objetivos. Determinar la proporción de alergia confirmada a amoxicilina en niños con sospecha diagnóstica, atendidos en una sección de alergia pediátrica. Población y métodos. Estudio descriptivo retrospectivo entre enero de 2009 y enero de 2017, en menores de 18 años con sospecha diagnóstica de alergia a amoxicilina. Se realizó el diagnóstico según interrogatorio y pruebas específicas. Resultados. Fueron incluidos 234 pacientes; se diagnosticó alergia a la amoxicilina en el 10,7 % (intervalo de confianza del 95 %: 7-15). Estos pacientes tenían mayor prevalencia de síntomas inmediatos (el 40 % vs. el 22 %, p = 0,048) y de exposición previa a betalactámicos (el 84 % vs. el 56 %, p = 0,007). Conclusión. La confirmación de alergia a la amoxicilina en niños derivados a especialistas fue del 10,7 %.

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Asthma, Family History of Drug Allergy, and Age Predict Amoxicillin Allergy in Children

Cited by 23 publications

References 30 publications

Recent developments and highlights in drug hypersensitivity

Recent developments and highlights in drug hypersensitivity

Diagnostic confirmation of amoxicillin allergy in children treated at a division of Pediatric Allergy

Confirmación diagnóstica de alergia a la amoxicilina en niños tratados en una sección de alergia pediátrica

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